Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,062 questions · 1,113 findings · 171 reviews · Headline outcomes only

No studies found 161 · 14.5%GRADE not reported 41 · 3.7%Very low 269 · 24.2%Low 321 · 28.8%Moderate 252 · 22.6%High 69 · 6.2%

Intervention not reported

The mean change of total recall on the SRT from baseline Scale from: 0 to 72 · Patients with memory disorder in multiple sclerosis
1 finding from 1 review

Intervention not reported

The mean change of total correct score on the 10/36 SRT from baseline Scale from: 0 to 40 · Patients with memory disorder in multiple sclerosis
1 finding from 1 review

Intervention not reported

The mean change of total correct score on the SDMT from baseline Scale from: 0 to infinity · Patients with memory disorder in multiple sclerosis
1 finding from 1 review

Intervention not reported

The mean change of total correct score on the PASAT (2+3 sec) from baseline Scale from: 0 to 120 · Patients with memory disorder in multiple sclerosis
1 finding from 1 review

Intervention not reported

The number of patients experiencing diarrhoea · Patients with memory disorder in multiple sclerosis

The intervention probably leads to higher the number of patients experiencing diarrhoea (moderate certainty).

1 finding from 1 review

Intervention not reported

The number of patients experiencing nausea · Patients with memory disorder in multiple sclerosis

The intervention showed no clear difference in the number of patients experiencing nausea (moderate certainty).

1 finding from 1 review

Intervention not reported

The number of patients experiencing abnormal dreams · Patients with memory disorder in multiple sclerosis

The intervention probably leads to higher the number of patients experiencing abnormal dreams (moderate certainty).

1 finding from 1 review

Intervention not reported

The annualised rate of relapse Scale from: 0 to infinity. · patients with relapsing‐remitting multiple sclerosis
1 finding from 1 review

Intervention not reported

The sum of the number of gadolinium‐enhancing T1‐weighted lesions Scale from: 0 to infinity. · patients with relapsing‐remitting multiple sclerosis
1 finding from 1 review

Intervention not reported

The number of patients with adverse effects · patients with relapsing‐remitting multiple sclerosis

The intervention showed no clear difference in the number of patients with adverse effects (low certainty).

1 finding from 1 review

Intervention not reported

The number of patients with serious adverse events · patients with relapsing‐remitting multiple sclerosis

The intervention showed no clear difference in the number of patients with serious adverse events (low certainty).

1 finding from 1 review

Intervention not reported

The number of patients who withdrew or dropped out from the study because of AEs · patients with relapsing‐remitting multiple sclerosis

The intervention showed no clear difference in the number of patients who withdrew or dropped out from the study… (low certainty).

1 finding from 1 review

Intervention not reported

The number of patients with disability progression · patients with relapsing‐remitting multiple sclerosis
1 finding from 1 review

Intervention not reported

The time to confirmed disease progression · patients with relapsing‐remitting multiple sclerosis
1 finding from 1 review

Intervention not reported

Sustained (6 months) EDSS increase after 3 years · patients with secondary progressive multiple sclerosis

The intervention showed no clear difference in sustained (6 months) EDSS increase after 3 years (high certainty).

1 finding from 1 review

Intervention not reported

Sustained (3 months) EDSS increase after 3 years · patients with secondary progressive multiple sclerosis

The intervention leads to lower sustained (3 months) EDSS increase after 3 years (high certainty).

1 finding from 1 review

Intervention not reported

Sustained (3 or 6 months) EDSS increase at 3 years in patients with pre study relapses · patients with secondary progressive multiple sclerosis

The intervention showed no clear difference in sustained (3 or 6 months) EDSS increase at 3 years in patients with… (high certainty).

1 finding from 1 review

Intervention not reported

Number of patients with at least one relapse during · patients with secondary progressive multiple sclerosis

The intervention leads to lower number of patients with at least one relapse during (high certainty).

1 finding from 1 review