Cochrane · systematic review · CD008876
Pharmacological treatment for memory disorder in multiple sclerosis
He, D, Zhang, Y, Dong, S, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
Multiple Sclerosis and Rare Diseases of the CNSAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 7 · 100%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Donepezil for memory disorder in multiple sclerosis
Population: Patients with memory disorder in multiple sclerosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
The mean change of total recall on the SRT from baseline Scale from: 0 to 72 | no estimate extracted | 2 studies · 189 participants | Moderate Downgraded: imprecision |
The mean change of total correct score on the 10/36 SRT from baseline Scale from: 0 to 40 | no estimate extracted | 2 studies · 189 participants | Moderate Downgraded: imprecision |
The mean change of total correct score on the SDMT from baseline Scale from: 0 to infinity | no estimate extracted | 2 studies · 189 participants | Moderate Downgraded: imprecision |
The mean change of total correct score on the PASAT (2+3 sec) from baseline Scale from: 0 to 120 | no estimate extracted | 2 studies · 189 participants | Moderate Downgraded: imprecision |
The number of patients experiencing diarrhoea | RR 3.88 [1.66, 9.05] | 2 studies · 189 participants | Moderate Downgraded: imprecision |
The number of patients experiencing nausea | RR 1.71 [0.93, 3.18] | 2 studies · 189 participants | Moderate Downgraded: imprecision |
The number of patients experiencing abnormal dreams | RR 2.91 [1.38, 6.14] | 2 studies · 189 participants | Moderate Downgraded: imprecision |