Cochrane · systematic review · CD009130
Rituximab for relapsing‐remitting multiple sclerosis
He, D, Guo, R, Zhang, F, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
Multiple Sclerosis and Rare Diseases of the CNSAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 28.6%Very low 0 · 0%Low 5 · 71.4%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Rituximab for relapsing‐remitting multiple sclerosis
Population: patients with relapsing‐remitting multiple sclerosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
The annualised rate of relapse Scale from: 0 to infinity. | no estimate extracted | 1 study · 104 participants | Low Downgraded: risk of bias, imprecision |
The sum of the number of gadolinium‐enhancing T1‐weighted lesions Scale from: 0 to infinity. | no estimate extracted | 1 study · 104 participants | Low Downgraded: risk of bias, imprecision |
The number of patients with adverse effects | RR 0.99 [0.94, 1.05] | 1 study · 104 participants | Low Downgraded: risk of bias, imprecision |
The number of patients with serious adverse events | RR 0.91 [0.33, 2.52] | 1 study · 104 participants | Low Downgraded: risk of bias, imprecision |
The number of patients who withdrew or dropped out from the study because of AEs | RR 0.76 [0.13, 4.35] | 1 study · 104 participants | Low Downgraded: risk of bias, imprecision |
The number of patients with disability progression | no estimate extracted | 0 studies · 0 participants | Ungraded |
The time to confirmed disease progression | no estimate extracted | 0 studies · 0 participants | Ungraded |