Findings

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Evidence found and GRADE certainty

2,539 questions · 2,602 findings · 424 reviews · Headline outcomes only

No studies found 572 · 22%GRADE not reported 189 · 7.3%Very low 527 · 20.3%Low 685 · 26.3%Moderate 514 · 19.8%High 115 · 4.4%

Omega‐3 fatty acids and antioxidants vs standard diet or placebo

Mortality within the longest · adults (aged 18 years or older), mechanically ventilated participants with ARDS as defined by the Berlin definition of ARDS or, for older…

Omega‐3 fatty acids and antioxidants showed no clear difference in all‐cause mortality (longest period reported) compared with placebo or standard nutrition (low certainty).

1 finding from 1 review

Omega‐3 vs placebo

Mental state: psychotic symptoms Average total score (PANSS, higher score = worse, scale from 30‐210) Long‐term (up to 7 years) · people in the prodromal stage of psychosis
1 finding from 1 review

Omega‐3 vs placebo

Satisfaction with treatment: 1. Leaving the study early ‐ long term · people in the prodromal stage of psychosis

Group A: omega‐3 fatty acids showed no clear difference in satisfaction with treatment: leaving the study early Long‐term… compared with placebo (low certainty).

1 finding from 1 review

Group B cognitive behavioural therapy: cognitive behavioural therapy + supportive therapy vs supportive therapy

Prodromal symptoms: transition to psychosis Endpoint data (events) · people in the prodromal stage of psychosis

It is very uncertain whether group B cognitive behavioural therapy: cognitive behavioural therapy… changes prodromal symptoms: transition to psychosis Long‐term (events) compared with supportive therapy (very low certainty).

1 finding from 1 review

Group B cognitive behavioural therapy: cognitive behavioural therapy (specific preventive intervention) + needs‐based intervention + risperidone vs needs‐based intervention

Prodromal symptoms: transition to psychosis Endpoint data (events) · people in the prodromal stage of psychosis

It is very uncertain whether group B cognitive behavioural therapy: cognitive behavioural therapy… changes prodromal symptoms: transition to psychosis Endpoint data (events)… compared with needs‐based intervention (very low certainty).

1 finding from 1 review

Group B cognitive behavioural therapy: cognitive behavioural therapy (specific preventive intervention) + needs‐based intervention + risperidone vs needs‐based intervention

Satisfaction with treatment: 1. Leaving the study early ‐ long term · people in the prodromal stage of psychosis

It is very uncertain whether group B cognitive behavioural therapy: cognitive behavioural therapy… changes satisfaction with treatment: leaving the study early (events)… compared with needs‐based intervention (very low certainty).

1 finding from 1 review

Cognitive training vs active control

Satisfaction with treatment: 1. Leaving the study early ‐ long term · people in the prodromal stage of psychosis

It is very uncertain whether group C other: cognitive training changes satisfaction with treatment: leaving the study early Endpoint data… compared with active control (tablet games) (very low certainty).

1 finding from 1 review

Group C other: family treatment vs enhanced care

Prodromal symptoms: transition to psychosis FACT Long‐term · people in the prodromal stage of psychosis

It is very uncertain whether group C other: family treatment changes prodromal symptoms: transition to psychosis FACT Long‐term compared with enhanced care (very low certainty).

1 finding from 1 review

Omega‐3 vs placebo

Prodromal symptoms: transition to psychosis Endpoint data (events) · people in the prodromal stage of psychosis

Group A: omega‐3 fatty acids may leads to lower prodromal symptoms: transition to psychosis Long‐term (events) compared with placebo (low certainty).

1 finding from 1 review

Group C other: family treatment vs enhanced care

Satisfaction with treatment: leaving the study early FACT Long‐term · people in the prodromal stage of psychosis

It is very uncertain whether group C other: family treatment changes satisfaction with treatment: leaving the study early FACT Long‐term compared with enhanced care (very low certainty).

1 finding from 1 review

Group C other: integrated treatment vs usual care

Prodromal symptoms: transition to psychosis Endpoint data (events) · people in the prodromal stage of psychosis

It is very uncertain whether group C other: integrated treatment changes prodromal symptoms: transition to psychosis Endpoint data (events)… compared with standard treatment (very low certainty).

1 finding from 1 review

Omega‐3 vs placebo

Global state: antipsychotic prescription Long‐term (events) · people in the prodromal stage of psychosis

Group A: omega‐3 fatty acids may leads to lower global state: antipsychotic prescription Long‐term (events) compared with placebo (low certainty).

1 finding from 1 review