Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

Prebiotic vs placebo

Withdrawals due to adverse events · people with histologically confirmed diagnosis of ulcerative colitis in remission

It is very uncertain whether prebiotics changes withdrawals due to adverse events (60 days to 6 months) compared with placebo (very low certainty).

1 finding from 1 review

Prebiotic vs placebo

Withdrawals due to adverse events · people with mild‐to‐moderate disease (Rachmilewitz index) or active disease (SCCAI score of 4 to 10)

It is very uncertain whether prebiotics changes withdrawals due to adverse events (14 days to 2 or 3 months) compared with placebo (very low certainty).

1 finding from 1 review

Test‐based attendance vs routine isolation after contact with a SARS‐CoV‐2 positive person

COVID‐related absenteeism from work Days absent per 1000 working days (over 13‐week · school staff

Test‐based attendance showed no clear difference in COVID‐related absenteeism from work Days absent per 1000 working… compared with routine isolation after contact with a SARS‐CoV‐2‐positive person (low certainty).

1 finding from 1 review

Favipiravir vs no treatment, supportive treatment, or other antiviral treatment

All‐cause mortality – at 28 to 30 days, or in‐hospital · people with confirmed COVID‐19

It is very uncertain whether favipiravir changes all‐cause mortality – at 28 to 30 days, or in‐hospital compared with no treatment, supportive treatment, or other antiviral treatment (very low certainty).

1 finding from 1 review

Ibuprofen vs morphine

Adverse events (reported in the first 7 days after the procedure) · children with acute postoperative pain

Ibuprofen probably leads to lower adverse events (reported in the first 7 days after the procedure) compared with morphine (moderate certainty).

1 finding from 1 review

Ibuprofen vs placebo

Adverse events (reported in the first 7 days after the procedure) · children with acute postoperative pain

Ibuprofen showed no clear difference in adverse events (reported in the first 7 days after the procedure) compared with placebo (low certainty).

1 finding from 1 review

Antibiotics vs placebo

Pain ‐ pain at 2 to 3 days · children with acute otitis media

Antibiotics leads to lower pain ‐ pain at 2 to 3 days compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Pain ‐ pain at 4 to 7 days · children with acute otitis media

Antibiotics showed no clear difference in pain ‐ pain at 4 to 7 days compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Pain ‐ pain at 10 to 12 days · children with acute otitis media

Antibiotics probably leads to lower pain ‐ pain at 10 to 12 days compared with placebo (moderate certainty).

1 finding from 1 review