Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,123 questions · 2,188 findings · 243 reviews

No studies found 493 · 22.5%GRADE not reported 160 · 7.3%Very low 600 · 27.4%Low 474 · 21.7%Moderate 364 · 16.6%High 97 · 4.4%

Pentoxifylline with antibiotics (any dose or duration) vs immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics

Necrotising enterocolitis · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes necrotising enterocolitis, any Bell stage compared with immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics (very low certainty).

1 finding from 1 review

Pentoxifylline with antibiotics (any dose or duration) vs pentoxifylline with antibiotics and immunoglobulin M‐enriched intravenous immunoglobulin

All‐cause mortality during hospital stay · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes all‐cause mortality during hospital stay compared with pentoxifylline with antibiotics and immunoglobulin M‐enriched… (very low certainty).

1 finding from 1 review

Antibiotic eardrops (with or without a corticosteroid) vs oral antibiotics

Resolution of ear discharge at short‐term

Antibiotic eardrops (with or without a corticosteroid) probably leads to higher resolution of ear discharge at short‐term compared with oral antibiotics (moderate certainty).

1 finding from 1 review

Antibiotic eardrops (with or without a corticosteroid) vs oral antibiotics

Resolution of ear discharge at intermediate‐term

Antibiotic eardrops (with or without a corticosteroid) probably leads to higher resolution of ear discharge at intermediate‐term compared with oral antibiotics (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Prostatitis symptoms: 'responders' Number of participants with a 25% or 6‐point decrease in NIH‐CPSI scores · participants with chronic prostatitis/chronic pelvic pain syndrome

Antibiotic therapy showed no clear difference in prostatitis symptoms: 'responders' Number of participants with a 25%… compared with placebo (low certainty).

1 finding from 1 review