Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,534 questions · 5,247 findings · 456 reviews

No studies found 1,142 · 21.8%GRADE not reported 1,503 · 28.6%Very low 1,040 · 19.8%Low 869 · 16.6%Moderate 554 · 10.6%High 139 · 2.6%

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Intervention not reported

Quality of life1 Paediatric Asthma Quality of Life Questionnaire (PAQLQ). Scale from: 1 (worse) to 7 (better). · children and adolescents aged 18 years and under studies with asthma
1 finding from 1 review

Intervention not reported

Exacerbations requiring a course of oral corticosteroids · children and adolescents aged 18 years and under studies with asthma

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Urgent asthma physician visits1 Number of times the child visited a physician's office/clinic for an asthma flare up · children and adolescents aged 18 years and under studies with asthma
1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Death · HIV‐positive, treatment‐naive children aged one to 12 years old

It is very uncertain whether IMMEDIATE initiation of cART changes death compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

CDC Category C disease (number of children) · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes CDC Category C disease (number of children) compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

CDC Category B disease (numbers of children) Peto Odds Ratio · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes CDC Category B disease (numbers of children) Peto Odds Ratio compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Proportion of children on ART with HIV‐RNA < 50 copies/ml · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes proportion of children on ART with HIV‐RNA < 50 copies/ml compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

CDC Category C disease (number of children) · HIV‐positive, treatment‐naive children aged one to 12 years old

It is very uncertain whether IMMEDIATE initiation of cART changes CDC Category C disease (number of children) compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

CDC Category B disease (numbers of children) Peto Odds Ratio · HIV‐positive, treatment‐naive children aged one to 12 years old

It is very uncertain whether IMMEDIATE initiation of cART changes CDC Category B disease (numbers of children) Peto Odds Ratio compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Proportion of children on ART with HIV‐RNA < 50 copies/ml · HIV‐positive, treatment‐naive children aged one to 12 years old

IMMEDIATE initiation of cART showed no clear difference in proportion of children on ART with HIV‐RNA < 50 copies/ml (Copy) compared with DEFERRED initiation of cART (low certainty).

1 finding from 1 review