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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,751 questions in 147 reviews · Pain, Palliative and Supportive Care
current versionsNo studies 361 · 20.6%Ungraded 87 · 5%Very low 625 · 35.7%Low 367 · 21%Moderate 232 · 13.2%High 79 · 4.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intervention NR Death · adults with neuropathic pain (3 studies in painful diabetic neuropathy and postherpetic neuralgia) Desipramine for neuropathic pain in adults (2014) · Cochrane | no estimate extracted | 5 studies · 177 participants | Ungraded |
Intervention NR At least 50% reduction in pain or equivalent · adults with complex regional pain syndrome type 1 (lower limb) Cervico‐thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR At least 30% reduction in pain · adults with complex regional pain syndrome type 1 (lower limb) Cervico‐thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Proportion below 30/100 mm on VAS · adults with complex regional pain syndrome type 1 (lower limb) Cervico‐thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome (2013) · Cochrane | no estimate extracted | 19 participants | Very low |
Intervention NR Patient Global Impression of Change: much or very much improved · adults with complex regional pain syndrome type 1 (lower limb) Cervico‐thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Adverse event withdrawals · adults with complex regional pain syndrome type 1 (lower limb) Cervico‐thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome (2013) · Cochrane | no estimate extracted | 20 participants | Very low |
Intervention NR Serious adverse events · adults with complex regional pain syndrome type 1 (lower limb) Cervico‐thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome (2013) · Cochrane | no estimate extracted | 20 participants | Very low |
Intervention NR Death · adults with complex regional pain syndrome type 1 (lower limb) Cervico‐thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Appetite improvement compared with placebo Subjective sense of appetite, responses to · cachexia anorexia syndrome Megestrol acetate for treatment of anorexia‐cachexia syndrome (2013) · Cochrane | RR 2.19 [1.41, 3.4] | 5 studies · 699 participants | Very low |
Intervention NR Weight improvement compared with placebo % of patients that improved their weight in kg · cachexia anorexia syndrome Megestrol acetate for treatment of anorexia‐cachexia syndrome (2013) · Cochrane | RR 1.51 [1.08, 2.11] | 10 studies · 1106 participants | Very low |
Intervention NR Appetite improvement compared to other drugs Questionnaire of appetite rating · cachexia anorexia syndrome Megestrol acetate for treatment of anorexia‐cachexia syndrome (2013) · Cochrane | RR 1.03 [0.64, 1.67] | 1 study · 475 participants | Low |
Intervention NR Weight improvement compared to other drugs % of patients that improved their weight in kg · cachexia anorexia syndrome Megestrol acetate for treatment of anorexia‐cachexia syndrome (2013) · Cochrane | RR 1.66 [1.09, 2.52] | 7 studies · 1131 participants | Very low |
Intervention NR Deaths · cachexia anorexia syndrome Megestrol acetate for treatment of anorexia‐cachexia syndrome (2013) · Cochrane | RR 1.42 [1.04, 1.94] | 10 studies · 1307 participants | Very low |
Intervention NR Thromboembolic phenomena including thrombophlebitis · cachexia anorexia syndrome Megestrol acetate for treatment of anorexia‐cachexia syndrome (2013) · Cochrane | RR 1.84 [1.07, 3.18] | 11 studies · 1544 participants | Very low |
Intervention NR Oedema · cachexia anorexia syndrome Megestrol acetate for treatment of anorexia‐cachexia syndrome (2013) · Cochrane | RR 1.36 [1.07, 1.72] | 12 studies · 2182 participants | Very low |
Transmucosal fentanyl vs placebo PID change at 15 min Opioids for the management of breakthrough pain in cancer patients (2013) · Cochrane | no estimate extracted | 7 studies · 1076 participants | High |
Lamotrigine 200 to 400 mg vs placebo At least 50% of maximum pain relief · neuropathic pain (three studies in painful diabetic neuropathy) Lamotrigine for chronic neuropathic pain and fibromyalgia in adults (2013) · Cochrane | no estimate extracted | NR | High |
Lamotrigine 200 to 400 mg vs placebo Participants with at least 1 adverse event (all conditions) · neuropathic pain (three studies in painful diabetic neuropathy) Lamotrigine for chronic neuropathic pain and fibromyalgia in adults (2013) · Cochrane | no estimate extracted | NR | High |
Lamotrigine 200 to 400 mg vs placebo Participants with a serious adverse event (all conditions) · neuropathic pain (three studies in painful diabetic neuropathy) Lamotrigine for chronic neuropathic pain and fibromyalgia in adults (2013) · Cochrane | no estimate extracted | NR | Very low |
Lamotrigine 200 to 400 mg vs placebo Participants with rash (all conditions) · neuropathic pain (three studies in painful diabetic neuropathy) Lamotrigine for chronic neuropathic pain and fibromyalgia in adults (2013) · Cochrane | no estimate extracted | NR | Moderate |
Lamotrigine 200 to 400 mg vs placebo Deaths (all conditions) · neuropathic pain (three studies in painful diabetic neuropathy) Lamotrigine for chronic neuropathic pain and fibromyalgia in adults (2013) · Cochrane | no estimate extracted | NR | Very low |
Intervention NR At least 50% of maximum pain relief over 4 to 6 hours · Adults with moderate or severe acute postoperative pain Single dose oral dexibuprofen [S(+)‐ibuprofen] for acute postoperative pain in adults (2013) · Cochrane | no estimate extracted | NR | Very low |
Intervention NR Participants with at least 1 adverse event · Adults with moderate or severe acute postoperative pain Single dose oral dexibuprofen [S(+)‐ibuprofen] for acute postoperative pain in adults (2013) · Cochrane | no estimate extracted | NR | Very low |
Intervention NR Participants with a serious adverse event · Adults with moderate or severe acute postoperative pain Single dose oral dexibuprofen [S(+)‐ibuprofen] for acute postoperative pain in adults (2013) · Cochrane | no estimate extracted | NR | Very low |
Intervention NR Deaths · Adults with moderate or severe acute postoperative pain Single dose oral dexibuprofen [S(+)‐ibuprofen] for acute postoperative pain in adults (2013) · Cochrane | no estimate extracted | NR | Very low |
Intervention NR Pain free response at 2 h · adults with migraine headache ‐ moderate or severe pain Ibuprofen with or without an antiemetic for acute migraine headaches in adults (2013) · Cochrane | no estimate extracted | NR | Moderate |
Intervention NR Headache relief at 2 h · adults with migraine headache ‐ moderate or severe pain Ibuprofen with or without an antiemetic for acute migraine headaches in adults (2013) · Cochrane | no estimate extracted | NR | Moderate |
Intervention NR Sustained pain‐free at 24 h · adults with migraine headache ‐ moderate or severe pain Ibuprofen with or without an antiemetic for acute migraine headaches in adults (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Sustained headache relief at 24 h · adults with migraine headache ‐ moderate or severe pain Ibuprofen with or without an antiemetic for acute migraine headaches in adults (2013) · Cochrane | no estimate extracted | NR | Moderate |
Intervention NR At least one AE · adults with migraine headache ‐ moderate or severe pain Ibuprofen with or without an antiemetic for acute migraine headaches in adults (2013) · Cochrane | no estimate extracted | NR | Moderate |
Intervention NR Serious AE · adults with migraine headache ‐ moderate or severe pain Ibuprofen with or without an antiemetic for acute migraine headaches in adults (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Pain free response at 2 h · adults with migraine headache ‐ moderate or severe pain Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults (2013) · Cochrane | no estimate extracted | NR | Low |
Intervention NR Headache relief at 2 h · adults with migraine headache ‐ moderate or severe pain Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults (2013) · Cochrane | no estimate extracted | NR | Low |
Intervention NR Headache relief at 1 h · adults with migraine headache ‐ moderate or severe pain Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults (2013) · Cochrane | no estimate extracted | NR | Low |
Intervention NR At least one AE · adults with migraine headache ‐ moderate or severe pain Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults (2013) · Cochrane | no estimate extracted | NR | Low |
Intervention NR Sustained pain‐free at 24 h · adults with migraine headache ‐ moderate or severe pain Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Sustained headache relief at 24 h · adults with migraine headache ‐ moderate or severe pain Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Serious AE · adults with migraine headache ‐ moderate or severe pain Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Pain‐free at 2 h · migraine headache ‐ moderate or severe pain Aspirin with or without an antiemetic for acute migraine headaches in adults (2013) · Cochrane | no estimate extracted | 6 studies · 2027 participants | Moderate |
Intervention NR Headache relief at 2 h · migraine headache ‐ moderate or severe pain Aspirin with or without an antiemetic for acute migraine headaches in adults (2013) · Cochrane | no estimate extracted | 6 studies · 2027 participants | Moderate |
Intervention NR Sustained pain‐free at 24 h · migraine headache ‐ moderate or severe pain Aspirin with or without an antiemetic for acute migraine headaches in adults (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Sustained headache relief at 24 h · migraine headache ‐ moderate or severe pain Aspirin with or without an antiemetic for acute migraine headaches in adults (2013) · Cochrane | no estimate extracted | 3 studies · 1142 participants | Moderate |
Intervention NR At least one AE · migraine headache ‐ moderate or severe pain Aspirin with or without an antiemetic for acute migraine headaches in adults (2013) · Cochrane | no estimate extracted | 5 studies · 1892 participants | Low |
Intervention NR Serious AE · migraine headache ‐ moderate or severe pain Aspirin with or without an antiemetic for acute migraine headaches in adults (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Pain‐free at 30 mins · adults with cluster headache Triptans for acute cluster headache (2013) · Cochrane | no estimate extracted | NR | Low |
Intervention NR Headache relief at 15 mins · adults with cluster headache Triptans for acute cluster headache (2013) · Cochrane | no estimate extracted | NR | Low |
Intervention NR At least one AE · adults with cluster headache Triptans for acute cluster headache (2013) · Cochrane | no estimate extracted | NR | Very low |
Intervention NR Serious AE · adults with cluster headache Triptans for acute cluster headache (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Pain‐free at 15 mins · adults with cluster headache Triptans for acute cluster headache (2013) · Cochrane | RR 2.6 [0.8, 8.5] | NR | Very low |
Intervention NR Headache relief at 30 mins · adults with cluster headache Triptans for acute cluster headache (2013) · Cochrane | no estimate extracted | NR | Low |