Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

948 questions · 998 findings · 100 reviews · Headline outcomes only

No studies found 233 · 23.3%GRADE not reported 40 · 4%Very low 203 · 20.3%Low 271 · 27.2%Moderate 176 · 17.6%High 75 · 7.5%

Provision of maize flour or maize flour products fortified with iron plus other vitamins and minerals vs unfortified maize flours or maize flour products

Anaemia · general population older than 2 years of age (including pregnant women), in Kenya and Mexico

It is very uncertain whether provision of maize flour or maize flour products fortified with iron… changes anaemia (defined as haemoglobin (Hb) below WHO cut‐off, adjusted for… compared with unfortified maize flours or maize flour products (very low certainty).

1 finding from 1 review

Provision of maize flour or maize flour products fortified with iron plus other vitamins and minerals vs unfortified maize flours or maize flour products

Iron deficiency (as defined by study authors, based on a biomarker of iron status) · general population older than 2 years of age (including pregnant women), in Kenya and Mexico

It is very uncertain whether provision of maize flour or maize flour products fortified with iron… changes iron deficiency (as defined by trialists, based on a biomarker of… compared with unfortified maize flours or maize flour products (very low certainty).

1 finding from 1 review

Provision of maize flour or maize flour products fortified with iron plus other vitamins and minerals vs unfortified maize flours or maize flour products

Any adverse effects (including constipation, nausea, vomiting, heartburn or diarrhoea, as measured by trialists) · general population older than 2 years of age (including pregnant women), in Kenya and Mexico

The review found no eligible studies for this question.

1 finding from 1 review

Homocysteine‐lowering interventions (Folic Acid, Vitamin B6 and Vitamin B12) vs placebo or usual care

Myocardial infarction · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (Vitamin B6 (pyridoxine;… showed no clear difference in myocardial infarction compared with placebo or standard care (high certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (Folic Acid, Vitamin B6 and Vitamin B12) vs placebo or usual care

Stroke · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (Vitamin B6 (pyridoxine;… leads to lower stroke compared with placebo or standard care (high certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (Folic Acid, Vitamin B6 and Vitamin B12) vs placebo or usual care

Death by any cause · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (Vitamin B6 (pyridoxine;… showed no clear difference in death by any cause compared with placebo or standard care (high certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (Folic Acid, Vitamin B6 and Vitamin B12) vs placebo or usual care

Adverse events · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (Vitamin B6 (pyridoxine;… showed no clear difference in adverse events compared with placebo or standard care (high certainty).

1 finding from 1 review

Oral nutritional supplements vs placebo

Ulcer healing · people with diabetes and foot ulcers

The review found no eligible studies for this question.

2 findings from 1 review

Preconception lifestyle advice on a combination of topics vs usual care or attention control

Reported behavioural changes on vitamin or mineral supplement intake: number of women with adequate use of folic acid supplement · people with infertility

Preconception lifestyle advice on a combination of topics showed no clear difference in reported behavioural changes on vitamin or mineral supplement… compared with routine care or attention control (low certainty).

1 finding from 1 review