Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,549 questions · 1,604 findings · 181 reviews

No studies found 258 · 16.1%GRADE not reported 69 · 4.3%Very low 337 · 21%Low 406 · 25.3%Moderate 410 · 25.6%High 124 · 7.7%

Intervention not reported

Anti‐thymocyte globulin plus glucocorticosteroids (1 RCT; 93 participants) · adults undergoing liver transplantation

It is very uncertain whether the intervention changes anti‐thymocyte globulin plus glucocorticosteroids (1 RCT; 93… (very low certainty).

1 finding from 1 review

Intervention not reported

Anti‐thymocyte globulin plus glucocorticosteroids (3 RCTs; 152 participants) · adults undergoing liver transplantation

It is very uncertain whether the intervention changes anti‐thymocyte globulin plus glucocorticosteroids (3 RCTs; 152… (very low certainty).

1 finding from 1 review

Atorvastatin vs placebo

Asthma exacerbations requiring hospitalisation or a course of steroids · people with asthma

The review found no eligible studies for this question.

1 finding from 1 review
  • Statins for asthma 2020 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Fixed‐dose combination aclidinium/formoterol vs aclidinium alone

Exacerbations requiring steroids or antibiotics or both: number of participants · patients with chronic obstructive pulmonary disease

Fixed‐dose combination aclidinium/formoterol showed no clear difference in exacerbations requiring steroids or antibiotics or both: number of… compared with aclidinium alone (moderate certainty).

1 finding from 1 review

Fixed‐dose combination aclidinium/formoterol vs placebo

Exacerbations requiring steroids or antibiotics or both: number of participants · patients with chronic obstructive pulmonary disease

Fixed‐dose combination aclidinium/formoterol showed no clear difference in exacerbations requiring steroids or antibiotics or both: number of… compared with placebo (moderate certainty).

1 finding from 1 review

Fixed‐dose combination aclidinium/formoterol vs formoterol

Exacerbations requiring steroids or antibiotics or both: number of participants · patients with chronic obstructive pulmonary disease

Fixed‐dose combination aclidinium/formoterol leads to lower exacerbations requiring steroids or antibiotics or both: number of… compared with formoterol (high certainty).

1 finding from 1 review

Intervention not reported

Number of participants requiring oral corticosteroids over the study period · Adults from minority groups with doctor diagnosed asthma

It is very uncertain whether the intervention changes number of participants requiring oral corticosteroids over the study… (very low certainty).

1 finding from 1 review

Intervention not reported

Antibiotic prescriptions (number of courses/person/year) **Corticosteroids not meta‐analysed · adults (> 18 years of age) with either COPD or recurrent acute exacerbations of chronic bronchitis

The intervention may leads to higher antibiotic prescriptions (number of courses/person/year)… (low certainty).

1 finding from 1 review