Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

949 questions · 1,008 findings · 130 reviews · Gynaecology and Fertility

No studies found 195 · 19.3%GRADE not reported 30 · 3%Very low 346 · 34.3%Low 323 · 32%Moderate 101 · 10%High 13 · 1.3%

Analysis 7 ‐ Collagen membrane with polyethylene glycol and glycerol vs Ringer's lactate

Incidence of adhesions ‐ de novo Incidence at second‐look laparoscopy · patients with adhesion prevention after gynaecological surgery

Analysis 7 ‐ Collagen membrane with polyethylene glycol and glycerol may leads to lower incidence of adhesions ‐ de novo Incidence at second‐look laparoscopy compared with ringer's lactate (low certainty).

1 finding from 1 review

GnRHa treatment vs placebo or no pretreatment

Operating time · women with uterine fibroids
3 findings from 1 review

GnRHa treatment vs placebo or no pretreatment

Intraoperative blood loss (mL) · women with uterine fibroids
3 findings from 1 review

GnRHa treatment vs placebo or no pretreatment

Blood transfusion · women with uterine fibroids

GnRHa treatment showed no clear difference in blood transfusions compared with no pretreatment or placebo before myomectomy (operative and… (low certainty).

3 findings from 1 review

GnRHa treatment vs placebo or no pretreatment

Overall postoperative morbidity · women with uterine fibroids

GnRHa treatment showed no clear difference in postoperative morbidity compared with no pretreatment or placebo before myomectomy (operative and… (low certainty).

3 findings from 1 review

Summary of findings table ‐ Progestogens vs placebo or no pretreatment

OHSS · ovarian stimulation protocols for women undergoing ART

The review found no eligible studies for this question.

2 findings from 1 review

Combined oral contraceptive pill vs no pretreatment

OHSS · women undergoing assisted reproduction

Combined oral contraceptive pill showed no clear difference in OHSS rate (COCP + Ant vs Ant) compared with no pretreatment (low certainty).

2 findings from 1 review

Oestrogen in combination with progestogen (sequential or continuous) vs placebo

Withdrawals due to adverse events · women with PMS

It is very uncertain whether oestrogen in combination with progestogen (sequential or continuous) changes withdrawal due to adverse events over 2 to 4 menstrual cycles1 compared with placebo (very low certainty).

1 finding from 1 review

Oestrogen in combination with progestogen (sequential or continuous) vs placebo

Specific adverse events · women with PMS

It is very uncertain whether oestrogen in combination with progestogen (sequential or continuous) changes specific adverse events over 2 to 4 menstrual cycles1 compared with placebo (very low certainty).

1 finding from 1 review

Dose comparison: oestrogen 100 µg patch vs 200 µg patch plus progestogen

Withdrawals due to adverse events · women with PMS

It is very uncertain whether dose comparison: oestrogen 100 µg patch changes adverse events ‐ withdrawal rates over 8 months' compared with 200 µg patch plus progestogen (very low certainty).

1 finding from 1 review