Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

929 questions · 946 findings · 295 reviews · Headline outcomes only

No studies found 150 · 15.9%GRADE not reported 47 · 5%Very low 312 · 33%Low 262 · 27.7%Moderate 138 · 14.6%High 37 · 3.9%

Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs iron folic acid (IFA)

Maternal iron deficiency at term or near term (as defined by authors of the trials, based on any indicator of iron status at 34 weeks' gestation or more) · women during pregnancy
1 finding from 1 review

Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs multiple micronutrients (MMN)

Maternal iron deficiency at term or near term (as defined by authors of the trials, based on any indicator of iron status at 34 weeks' gestation or more) · women during pregnancy
1 finding from 1 review

Intraoperative 5‐Fluorouracil vs placebo or control

Failure at 12 months Need for repeat surgery or uncontrolled IOP (usually more than 22 mm Hg) despite additional topical or systemic medications · participants with glaucoma surgery

Intraoperative 5‐Fluorouracil leads to lower failure at 12 months Need for repeat surgery or uncontrolled IOP… compared with placebo or control (high certainty).

1 finding from 1 review

Nocturnal ventilation vs no ventilation

Mortality at 1 year (or more) · patients with neuromuscular and chest wall disorders and chronic hypoventilation

It is very uncertain whether nocturnal ventilation changes mortality at 1 year (or more) compared with no ventilation (very low certainty).

1 finding from 1 review

Volume‐cycled ventilation vs pressure‐cycled ventilation

Mortality at 1 year (or more) Not measured ‐ data reported for mortality at 3 months · patients with neuromuscular and chest wall disorders and chronic hypoventilation

It is very uncertain whether volume‐cycled ventilation changes mortality at 1 year (or more) Not measured ‐ data reported for… compared with pressure‐cycled ventilation (very low certainty).

1 finding from 1 review

IVIg vs PE

Number improved by 1 or more disability grades after 4 weeks · patients with Guillain‐Barré syndrome

IVIg showed no clear difference in number improved by 1 or more disability grades after 4 weeks compared with PE (moderate certainty).

1 finding from 1 review

Summary of findings ‐ Inhaled mannitol vs placebo

Hospitalisations Number of participants experiencing one of more hospitalisations. · people with bronchiectasis

Inhaled mannitol showed no clear difference in hospitalisations Number of participants experiencing one of more… compared with placebo (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

Two or more sexual partners in last year · low and high‐risk populations

Structural and community‐level interventions for increasing condom use showed no clear difference in two or more sexual partners in last year compared with standard care (moderate certainty).

1 finding from 1 review

Laser therapy vs Photodynamic therapy

Dysphagia improvement (2‐point grade or more) · patients with dysphagia in oesophageal cancer

Laser showed no clear difference in dysphagia improvement (2‐point grade or more) compared with photodynamic therapy (PDT) (moderate certainty).

1 finding from 1 review