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What do systematic reviews say?

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Evidence found and GRADE certainty

1,822 questions · 1,891 findings · 321 reviews · Headline outcomes only

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No studies found 279 · 14.8%GRADE not reported 46 · 2.4%Very low 524 · 27.7%Low 571 · 30.2%Moderate 330 · 17.5%High 141 · 7.5%

Clonidine vs placebo or no treatment

Number requiring additional analgesia at any time postoperatively ‐ high dose clonidine, studies with lower risk of bias · patients with postoperative pain

Clonidine probably leads to lower number requiring additional analgesia at any time postoperatively ‐… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Yoga in addition to standard care vs standard‐of‐care therapy

Quality of sleep · participants with haematological malignancies

It is very uncertain whether yoga in addition to standard care changes quality of sleep Scale from: 0 to 21. Higher scores indicate a lower… compared with standard care only (very low certainty).

1 finding from 1 review

Intervention not reported

TDI Total scores range from ‐ 9 to +9. The lower the score, the greater the deterioration in severity of dyspnoea, MCID ≥ 1 · 18 to 80 years of age with bronchiectasis

The intervention may leads to higher TDI Total scores range from ‐ 9 to +9. The lower the score, the… (low certainty).

1 finding from 1 review