What do systematic reviews say?

Loratadine 10 mg vs placebo

Loratadine 10 mg showed no clear difference in good or excellent response Global assessment of symptom scores compared with placebo (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.86 [0.91, 3.79]
  2 studies · 124 participants
  Low

Loratadine 10 mg vs cetirizine (antihistamine)

Loratadine 10 mg showed no clear difference in complete cessation of urticaria Global assessment of symptom scores compared with cetirizine 10 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.05 [0.76, 1.43]
  2 studies · 103 participants
  Low

Loratadine 10 mg vs desloratadine 5 mg

Loratadine 10 mg showed no clear difference in good or excellent response: intermediate‐term duration of… compared with desloratadine 5 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.04 [0.64, 1.71]
  3 studies · 410 participants
  Low

Loratadine 10 mg vs mizolastine 10 mg

It is very uncertain whether loratadine 10 mg changes complete cessation of urticaria: intermediate‐term duration of… compared with mizolastine 10 mg (very low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 0.86 [0.64, 1.16]
  3 studies · 316 participants
  Very low

Loratadine 10 mg vs mizolastine 10 mg

Loratadine 10 mg showed no clear difference in good or excellent response: intermediate‐term duration of… compared with mizolastine 10 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 0.88 [0.55, 1.42]
  3 studies · 314 participants
  Low

Loratadine 10 mg vs emedastine 2 mg

Loratadine 10 mg showed no clear difference in complete cessation of urticaria: intermediate‐term duration of… compared with emedastine 2 mg (moderate certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.04 [0.78, 1.39]
  1 study · 161 participants
  Moderate

Loratadine 10 mg vs emedastine 2 mg

Loratadine 10 mg showed no clear difference in good or excellent response: intermediate‐term duration of… compared with emedastine 2 mg (moderate certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.09 [0.96, 1.24]
  1 study · 160 participants
  Moderate

Loratadine 10 mg vs hydroxyzine 25 mg

Loratadine 10 mg showed no clear difference in complete suppression of urticaria: short‐term duration of… compared with hydroxyzine 25 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1 [0.32, 3.1]
  1 study · 12 participants
  Low

Desloratadine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 46 participants
  Low

Desloratadine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 46 participants
  Low

Desloratadine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 46 participants
  Low

Desloratadine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 80 participants
  Low

Levocetirizine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Low

Levocetirizine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Low

Tranexamic acid vs placebo

Tranexamic acid may leads to lower rebleeding Clinical and endoscopic assessment compared with placebo (low certainty).

• Tranexamic acid for upper gastrointestinal bleeding 2014 · Cochrane Headline outcomes only
  RR 0.72
  7 studies · 1651 participants
  Low

Tranexamic acid vs placebo

Tranexamic acid probably leads to higher any thromboembolic event Clinical and radiological assessment compared with placebo (moderate certainty).

• Tranexamic acid for upper gastrointestinal bleeding 2014 · Cochrane Headline outcomes only
  RR 1.86
  4 studies · 1095 participants
  Moderate

Tranexamic acid vs cimetidine or lansoprazole

Tranexamic acid probably leads to lower rebleeding Clinical and endoscopic assessment compared with cimetidine or lansoprazole (moderate certainty).

• Tranexamic acid for upper gastrointestinal bleeding 2014 · Cochrane Headline outcomes only
  RR 0.87
  2 studies · 720 participants
  Moderate

SULPIRIDE vs placebo

The review found no eligible studies for this question.

• Sulpiride versus placebo for schizophrenia 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Endoscopic vs open or mini‐open carpal tunnel release

• Endoscopic release for carpal tunnel syndrome 2014 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 551 participants
  Low

Endoscopic vs open or mini‐open carpal tunnel release

• Endoscopic release for carpal tunnel syndrome 2014 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 551 participants
  Low