Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,534 questions · 5,247 findings · 456 reviews

No studies found 1,142 · 21.8%GRADE not reported 1,503 · 28.6%Very low 1,040 · 19.8%Low 869 · 16.6%Moderate 554 · 10.6%High 139 · 2.6%

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Intervention not reported

Incidence of Pneumocystis carinii pneumonia infection in children with cancer ‐ trimethoprim‐sulfamethoxazole prophylaxis only · children with cancers aged 12 years and under

The intervention probably leads to lower incidence of Pneumocystis carinii pneumonia infection in children… (moderate certainty).

1 finding from 1 review

Intervention not reported

Mortality in children with HIV infection ‐ co‐trimoxazole prophylaxis only · children with HIV infection aged 12 years and under

The intervention probably leads to lower mortality in children with HIV infection ‐ co‐trimoxazole… (moderate certainty).

1 finding from 1 review

Intervention not reported

Mortality in children with HIV infection ‐ isoniazid prophylaxis only · children with HIV infection aged 12 years and under

The intervention showed no clear difference in mortality in children with HIV infection ‐ isoniazid prophylaxis only (low certainty).

1 finding from 1 review

Intervention not reported

Incidence of adverse events ‐ co‐trimoxazole prophylaxis only · children with HIV infection aged 12 years and under

The intervention showed no clear difference in incidence of adverse events ‐ co‐trimoxazole prophylaxis only (moderate certainty).

1 finding from 1 review

Intervention not reported

Incidence of Pseudomonas infection in children with cystic fibrosis ‐ ciprofloxacin prophylaxis only · children with cystic fibrosis aged 12 years and under

The intervention showed no clear difference in incidence of Pseudomonas infection in children with cystic fibrosis… (moderate certainty).

1 finding from 1 review

Intervention not reported

Child cognitive ability As assessed by the Griffith Mental Development scale at 18‐month · children younger than five years of age and their families

It is very uncertain whether the intervention changes child cognitive ability As assessed by the Griffith Mental… (very low certainty).

1 finding from 1 review

Intervention not reported

Child psychosocial development Parents reporting their child develops abnormally · children younger than five years of age and their families

It is very uncertain whether the intervention changes child psychosocial development Parents reporting their child… (very low certainty).

1 finding from 1 review

Intervention not reported

Paid maternal employment Mothers in full‐time or part‐time employment · children younger than five years of age and their families

It is very uncertain whether the intervention changes paid maternal employment Mothers in full‐time or part‐time employment (very low certainty).

1 finding from 1 review

Intervention not reported

Paid maternal employment Maternal hours per week in paid employment · children younger than five years of age and their families

It is very uncertain whether the intervention changes paid maternal employment Maternal hours per week in paid employment (very low certainty).

1 finding from 1 review

Intervention not reported

Household income Households with weekly income > £200 · children younger than five years of age and their families

It is very uncertain whether the intervention changes household income Households with weekly income > £200 (very low certainty).

1 finding from 1 review