Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,234 questions · 3,357 findings · 396 reviews

No studies found 803 · 23.9%GRADE not reported 270 · 8%Very low 757 · 22.5%Low 859 · 25.6%Moderate 486 · 14.5%High 182 · 5.4%

Topical triamcinolone acetonide vs Topical ciclosporin

Pain (mean VAS score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide showed no clear difference in pain (mean VAS score) compared with topical ciclosporin; GRADE not reported.

1 finding from 1 review

Topical triamcinolone acetonide vs pimecrolimus 1%

Pain (mean VAS score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide showed no clear difference in pain (mean VAS score) compared with topical pimecrolimus; GRADE not reported.

1 finding from 1 review

Topical triamcinolone acetonide vs Photodynamic therapy

Pain (mean score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical triamcinolone acetonide changes pain (mean score) compared with photodynamic therapy (very low certainty).

1 finding from 1 review

Clindamycin plus aminoglycoside vs other regimens

Severe complication ‐ lincosamides versus cephalosporins · women with postpartum endometritis

It is very uncertain whether clindamycin plus aminoglycoside changes severe complication ‐ lincosamides versus cephalosporins compared with any other regimen (very low certainty).

1 finding from 1 review

Clindamycin plus aminoglycoside vs other regimens

Wound infection · women with postpartum endometritis

Clindamycin plus aminoglycoside may leads to lower wound infection ‐ lincosamides versus cephalosporins compared with any other regimen (low certainty).

2 findings from 1 review

Clindamycin plus aminoglycoside vs other regimens

Allergic reaction · women with postpartum endometritis

Clindamycin plus aminoglycoside showed no clear difference in allergic reaction ‐ lincosamides versus cephalosporins compared with any other regimen (low certainty).

2 findings from 1 review

Low dose isotretinoin 0.3 mg/kg vs doxycycline

Participant‐assessed improvement in rosacea severity · Participants with rosacea

Low dose isotretinoin 0.3 mg/kg leads to higher participant‐assessed improvement in rosacea severity1 Good to… compared with doxycycline 50‐100 mg (high certainty).

1 finding from 1 review

Low dose isotretinoin 0.3 mg/kg vs doxycycline

Proportion of participants with adverse event · Participants with rosacea

Low dose isotretinoin 0.3 mg/kg showed no clear difference in proportion of participants with adverse event compared with doxycycline 50‐100 mg (high certainty).

1 finding from 1 review

Low dose isotretinoin 0.3 mg/kg vs doxycycline

Physician‐assessed improvement in rosacea severity · Participants with rosacea

Low dose isotretinoin 0.3 mg/kg leads to higher physician‐assessed improvement in rosacea severity1 Complete… compared with doxycycline 50‐100 mg (high certainty).

1 finding from 1 review

Low dose isotretinoin 0.3 mg/kg vs doxycycline

Assessment of erythema or telangiectasia Improved or healed · Participants with rosacea

Low dose isotretinoin 0.3 mg/kg showed no clear difference in assessment of erythema or telangiectasia Improved or healed compared with doxycycline 50‐100 mg (high certainty).

1 finding from 1 review