Question · asked by 1 review
Low dose isotretinoin 0.3 mg/kg vs doxycycline: Proportion of participants with adverse event
- Population
- Participants with rosacea
- Intervention
- Low dose isotretinoin 0.3 mg/kg
- Comparison
- doxycycline
- Outcome
- Proportion of participants with adverse event
Low dose isotretinoin 0.3 mg/kg showed no clear difference in proportion of participants with adverse event compared with doxycycline 50‐100 mg (high certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Low dose isotretinoin 0.3 mg/kg vs doxycycline 50‐100 mg Proportion of participants with adverse event · Participants with rosacea Low dose isotretinoin 0.3 mg/kg showed no clear difference in proportion of participants with adverse event compared with doxycycline 50‐100 mg (high certainty). Interventions for rosacea (2015) · Cochrane Headline outcomes only | RR 1.19 [0.74, 1.92] | 1 study · 299 participants | High |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for rosacea 2015 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.