Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,539 questions · 2,602 findings · 424 reviews · Headline outcomes only

No studies found 572 · 22%GRADE not reported 189 · 7.3%Very low 527 · 20.3%Low 685 · 26.3%Moderate 514 · 19.8%High 115 · 4.4%

Behavioural activation vs any comparator

Treatment efficacy for depression (long term: 24 months) · depression in adults with non‐communicable diseases

Behavioural activation showed no clear difference in treatment efficacy for depression (long term: 24 months) compared with any comparator (moderate certainty).

1 finding from 1 review

Intervention not reported

Mortality at longest · adult (≥ 18 years of age) patients receiving mechanical ventilation (via either an endotracheal tube or a tracheostomy) for acute…

It is very uncertain whether the intervention changes mortality at longest (very low certainty).

1 finding from 1 review

Corticosteroids vs placebo or usual care

Number of participants with adverse events ‐ superinfection (up to longest · children and adults with sepsis

Corticosteroids showed no clear difference in number of participants with adverse events ‐ superinfection (up to… compared with placebo or usual care (moderate certainty).

1 finding from 1 review

Intervention not reported

Smoking abstinence at longest · People who smoke or who have recently quit

The intervention showed no clear difference in smoking abstinence at longest (low certainty).

1 finding from 1 review

Intervention not reported

Relapse prevention at longest · People who smoke or who have recently quit

It is very uncertain whether the intervention changes relapse prevention at longest (very low certainty).

1 finding from 1 review