Findings

What do systematic reviews say?

627 questions · 638 findings · 45 reviews

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No studies found 89 · 13.9%GRADE not reported 37 · 5.8%Very low 221 · 34.6%Low 181 · 28.4%Moderate 92 · 14.4%High 18 · 2.8%

Second generation antidepressant vs placebo medication

Depressive symptoms · patients with depressive disorders in children and adolescents

1 finding from 1 review

Newer generation antidepressants for depressive disorders in children and adolescents 2012 · Cochrane Headline outcomes only
no estimate extracted
14 studies · 2490 participants
Low

Tricyclic antidepressants vs control

Pain < 1 week VAS scale 0 to 100 mm · patients with pain management in rheumatoid arthritis

1 finding from 1 review

Antidepressants for pain management in rheumatoid arthritis 2011 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Tricyclic antidepressants vs control

Pain 1 to 6 weeks Any pain measurement scale · patients with pain management in rheumatoid arthritis

1 finding from 1 review

Antidepressants for pain management in rheumatoid arthritis 2011 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 482 participants
Very low

Tricyclic antidepressants vs control

Pain > 6 weeks Any pain measurement scale · patients with pain management in rheumatoid arthritis

1 finding from 1 review

Antidepressants for pain management in rheumatoid arthritis 2011 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 368 participants
Very low

Tricyclic antidepressants vs control

Functional Status Health Assessment Questionnaire (HAQ) scale 0 to 3 · patients with pain management in rheumatoid arthritis

1 finding from 1 review

Antidepressants for pain management in rheumatoid arthritis 2011 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
Low

Tricyclic antidepressants vs control

Withdrawals due to adverse events · patients with pain management in rheumatoid arthritis

It is very uncertain whether tricyclic antidepressant changes number of Withdrawals due to Adverse Events patient interview compared with control (very low certainty).

1 finding from 1 review

Antidepressants for pain management in rheumatoid arthritis 2011 · Cochrane Headline outcomes only
RR 0.98 [0.59, 1.64]
6 studies · 455 participants
Very low

Tricyclic antidepressants vs control

Total number of adverse events patient interview · patients with pain management in rheumatoid arthritis

It is very uncertain whether tricyclic antidepressant changes total number of adverse events patient interview compared with control (very low certainty).

1 finding from 1 review

Antidepressants for pain management in rheumatoid arthritis 2011 · Cochrane Headline outcomes only
RR 1.83 [1.01, 3.3]
6 studies · 455 participants
Very low