Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

696 questions · 700 findings · 53 reviews · Anaesthesia

No studies found 107 · 15.3%GRADE not reported 151 · 21.6%Very low 144 · 20.6%Low 178 · 25.4%Moderate 97 · 13.9%High 23 · 3.3%

Larger traumatic needles vs smaller traumatic needles

Adverse events: backache · patients undergoing lumbar punctures with traumatic needles (Quincke, Greene, Hingson Ferguson, Lutz, Brace, Rovenstine, Lemmon)

Larger traumatic needles probably leads to lower adverse event: backache compared with smaller traumatic needles (moderate certainty).

1 finding from 1 review

Larger traumatic needles vs smaller traumatic needles

Severe PDPH · patients undergoing lumbar punctures with traumatic needles (Quincke, Greene, Hingson Ferguson, Lutz, Brace, Rovenstine, Lemmon)

Larger traumatic needles showed no clear difference in severe PDPH compared with smaller traumatic needles (low certainty).

1 finding from 1 review

Intervention not reported

Awareness Postoperative interview1 · patients with decreasing recall of events during surgery

It is very uncertain whether the intervention changes awareness Postoperative interview1 (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse effects of intraoperative wakefulness and/or postoperative awareness (i.e. post‐traumatic stress syndrome, myocardial infarction, cardiac arrest, etc.) · patients with decreasing recall of events during surgery

The review found no eligible studies for this question.

1 finding from 1 review

Active body surface warming systems vs control

Major cardiovascular complications (cardiovascular death, non‐fatal myocardial infarction, non‐fatal stroke, and non‐fatal cardiac arrest) · adults undergoing surgery

Active body surface warming systems showed no clear difference in major cardiovascular complications (cardiovascular death, non‐fatal… compared with control (low certainty).

1 finding from 1 review

CHRONIC: ACEi or ARB vs placebo

All‐cause mortality · Patients undergoing any type of surgery under general anaesthesia receiving ACEIs or ARBs perioperatively

It is very uncertain whether ACEIs or ARBs changes all‐cause mortality compared with placebo (very low certainty).

1 finding from 1 review

CHRONIC: ACEi or ARB vs placebo

Risk of acute myocardial ischaemia · Patients undergoing any type of surgery under general anaesthesia receiving ACEIs or ARBs perioperatively

It is very uncertain whether ACEIs or ARBs changes risk of acute myocardial ischaemia compared with placebo (very low certainty).

1 finding from 1 review

CHRONIC: ACEi or ARB vs placebo

Rate of perioperative cerebrovascular complications · Patients undergoing any type of surgery under general anaesthesia receiving ACEIs or ARBs perioperatively

It is very uncertain whether ACEIs or ARBs changes rate of perioperative cerebrovascular complications compared with placebo (very low certainty).

1 finding from 1 review