Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,281 questions · 1,307 findings · 212 reviews

No studies found 256 · 19.6%GRADE not reported 125 · 9.6%Very low 266 · 20.4%Low 403 · 30.8%Moderate 208 · 15.9%High 49 · 3.7%

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Recurrent oral ulceration prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in recurrent oral ulceration between CLWH with and without ART (very low certainty).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Oral hairy leukoplakia prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in oral hairy leukoplakia between CLWH with and without ART (very low certainty).

1 finding from 1 review

Laser trabeculoplasty vs medication

Failure to stabilise visual field progression (as defined by study investigators) · people with open‐angle glaucoma

Laser trabeculoplasty showed no clear difference in failure to stabilise visual field progression (as defined by study… compared with medication (moderate certainty).

1 finding from 1 review

Laser trabeculoplasty vs medication

Failure to stabilise optic neuropathy progression (as defined by study investigators) · people with open‐angle glaucoma

It is very uncertain whether laser trabeculoplasty changes failure to stabilise optic neuropathy progression (as defined by… compared with medication (very low certainty).

1 finding from 1 review

Acupuncture vs medication

Overactive bladder symptoms cured or improved · Adults with overactive bladder (OAB)

Acupuncture may leads to higher overactive bladder symptoms cured or improved compared with medication (low certainty).

1 finding from 1 review

Acupuncture vs medication

Presence or absence of urinary urgency · Adults with overactive bladder (OAB)

It is very uncertain whether acupuncture changes presence or absence of urinary urgency compared with medication (very low certainty).

1 finding from 1 review

Acupuncture vs medication

Episodes of urinary incontinence in a 24‐hour period · Adults with overactive bladder (OAB)

It is very uncertain whether acupuncture changes episodes of urinary incontinence in a 24‐hour period compared with medication (very low certainty).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Mucosal hyperpigmentation prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in mucosal hyperpigmentation between CLWH with and without ART (very low certainty).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Chronic herpes simplex infection prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in chronic herpes simplex infection between CLWH with and without ART (very low certainty).

1 finding from 1 review

CBT vs alternative treatment

Adverse events · People aged 12 years and over with painful TMD lasting 3 months or longer
1 finding from 1 review
  • SoF: 3 studies reported minor adverse events in the control group; 1 study reported minor adverse events in psychological therapy group; 1 study reported that there were no adverse events. Results: NCT00066937 minor…
    5 studies
    Very low

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Caries experience · Children and adolescents (<18 years) living with HIV (CLWH)

ART was not associated with a significant difference in dental caries experience among CLWH (very low certainty).

1 finding from 1 review