Benzoyl peroxide vs erythromycin
Adverse event data · participants with acne
1 finding from 1 review
- no estimate extracted1 study · 89 participantsVery low
Findings
What do systematic reviews say?
2,640 questions · 2,709 findings · 446 reviews
No studies found 593 · 21.9%GRADE not reported 241 · 8.9%Very low 538 · 19.9%Low 706 · 26.1%Moderate 516 · 19%High 115 · 4.2%
Benzoyl peroxide vs salicylic acid
Participant's global self‐assessment of improvement (long‐term data) ‐ not measured · participants with acne
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Benzoyl peroxide vs salicylic acid
Withdrawals due to adverse events · participants with acne
1 finding from 1 review
- no estimate extracted1 study · 59 participantsVery low
Benzoyl peroxide vs placebo or no treatment
Adverse effects (side effects; treatment withdrawals) · participants with acne
Benzoyl peroxide may leads to higher withdrawal due to adverse effects (long‐term data) Treatment… compared with placebo or no treatment (low certainty).
1 finding from 1 review
- RR 2.13 [1.55, 2.93]24 studies · 13744 participantsLow
Benzoyl peroxide vs placebo or no treatment
Total number of participants with any adverse events (long‐term data) Treatment duration: range 10 weeks to 12 weeks · participants with acne
It is very uncertain whether benzoyl peroxide changes total number of participants with any adverse events (long‐term… compared with placebo or no treatment (very low certainty).
1 finding from 1 review
- RR 1.4 [1.15, 1.7]21 studies · 11028 participantsVery low
Benzoyl peroxide vs adapalene
Participant's global self‐assessment of improvement (long‐term data) · participants with acne
Benzoyl peroxide showed no clear difference in participant's global self‐assessment of improvement (long‐term data) compared with adapalene (low certainty).
1 finding from 1 review
- RR 0.99 [0.9, 1.1]5 studies · 1472 participantsLow
Benzoyl peroxide vs adapalene
Withdrawals due to adverse outcomes · participants with acne
It is very uncertain whether benzoyl peroxide changes withdrawal due to adverse effects (long‐term data) Treatment… compared with adapalene (very low certainty).
1 finding from 1 review
- RR 1.85 [0.94, 3.64]11 studies · 3295 participantsVery low
Benzoyl peroxide vs adapalene
Adverse event data · participants with acne
It is very uncertain whether benzoyl peroxide changes total number of participants with any adverse events (long‐term… compared with adapalene (very low certainty).
1 finding from 1 review
- RR 0.71 [0.5, 1]7 studies · 2120 participantsVery low
Benzoyl peroxide vs clindamycin
Participant's global self‐assessment of improvement (long‐term data) · participants with acne
Benzoyl peroxide showed no clear difference in participant's global self‐assessment of improvement (long‐term data) compared with clindamycin (low certainty).
1 finding from 1 review
- RR 0.95 [0.68, 1.34]1 study · 240 participantsLow
Benzoyl peroxide vs clindamycin
Adverse effects (side effects; treatment withdrawals) · participants with acne
It is very uncertain whether benzoyl peroxide changes withdrawal due to adverse effects (long‐term data) Treatment… compared with clindamycin (very low certainty).
1 finding from 1 review
- RR 1.93 [0.9, 4.11]8 studies · 3330 participantsVery low
Benzoyl peroxide vs clindamycin
Total number of participants with any adverse events (long‐term data) Treatment duration: range 10 weeks to 12 weeks · participants with acne
Benzoyl peroxide showed no clear difference in total number of participants with any adverse events (long‐term… compared with clindamycin (moderate certainty).
1 finding from 1 review
- RR 1.24 [0.97, 1.58]6 studies · 3018 participantsModerate
Azelaic acid vs adapalene
Participants' global self‐assessment of acne improvement · participants with acne
It is very uncertain whether azelaic acid changes participants' global self‐assessment of acne improvement Improved to… compared with adapalene (very low certainty).
1 finding from 1 review
- Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes onlyRR 0.89 [0.68, 1.17]1 study · 55 participantsVery low
Azelaic acid vs clindamycin
Treatment withdrawal · participants with acne
Azelaic acid showed no clear difference in withdrawal for any reason (long term: treatment duration > 8 weeks) compared with clindamycin (low certainty).
1 finding from 1 review
- Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes onlyRR 1.3 [0.48, 3.56]2 studies · 329 participantsLow
Azelaic acid vs clindamycin
Minor adverse events · participants with acne
Azelaic acid showed no clear difference in total number of participants who experienced at least one minor… compared with clindamycin (low certainty).
1 finding from 1 review
- Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes onlyRR 1.5 [0.67, 3.35]1 study · 100 participantsLow
Azelaic acid vs tretinoin
Participants' global self‐assessment of acne improvement Good to excellent improvement (long term: treatment duration > 8 weeks) · participants with acne
Azelaic acid showed no clear difference in participants' global self‐assessment of acne improvement Good to… compared with tretinoin (moderate certainty).
1 finding from 1 review
- Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes onlyRR 0.94 [0.78, 1.14]1 study · 289 participantsModerate
Azelaic acid vs tretinoin
Treatment withdrawal · participants with acne
Azelaic acid showed no clear difference in withdrawal for any reason (long term: treatment duration > 8 weeks) compared with tretinoin (low certainty).
1 finding from 1 review
- Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes onlyRR 0.66 [0.29, 1.47]2 studies · 309 participantsLow
Azelaic acid vs adapalene
Treatment withdrawal · participants with acne
It is very uncertain whether azelaic acid changes withdrawal for any reason (long term: treatment duration > 8 weeks) compared with adapalene (very low certainty).
1 finding from 1 review
- Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes onlyRR 2.64 [0.33, 20.99]1 study · 55 participantsVery low
Salicylic acid vs tretinoin
Participants' global self‐assessment of acne improvement Moderate to excellent improvement (long term: treatment duration > 8 weeks) · participants with acne
Salicylic acid showed no clear difference in participants' global self‐assessment of acne improvement Moderate to… compared with tretinoin (low certainty).
1 finding from 1 review
- Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes onlyRR 1 [0.92, 1.09]1 study · 46 participantsLow
Salicylic acid vs tretinoin
Treatment withdrawal · participants with acne
1 finding from 1 review
- Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 74 participantsLow
Salicylic acid vs tretinoin
Minor adverse events · participants with acne
It is very uncertain whether salicylic acid changes total number of participants who experienced at least one minor… compared with tretinoin (very low certainty).
1 finding from 1 review
- Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes onlyRR 1.37 [0.66, 2.87]2 studies · 74 participantsVery low