Question · asked by 1 review
Azelaic acid vs tretinoin: Participants' global self‐assessment of acne improvement Good to excellent improvement (long term: treatment duration > 8 weeks)
- Population
- participants with acne
- Intervention
- Azelaic acid
- Comparison
- tretinoin
- Outcome
- Participants' global self‐assessment of acne improvement Good to excellent improvement (long term: treatment duration > 8 weeks)
Azelaic acid showed no clear difference in participants' global self‐assessment of acne improvement Good to… compared with tretinoin (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Azelaic acid vs tretinoin Participants' global self‐assessment of acne improvement Good to excellent improvement (long term: treatment duration > 8 weeks) · participants with acne Azelaic acid showed no clear difference in participants' global self‐assessment of acne improvement Good to… compared with tretinoin (moderate certainty). Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne (2020) · Cochrane Headline outcomes only | RR 0.94 [0.78, 1.14] | 1 study · 289 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.