Findings

What do systematic reviews say?

1,520 questions · 1,575 findings · 175 reviews · Headline outcomes only

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No studies found 239 · 15.2%GRADE not reported 59 · 3.7%Very low 337 · 21.4%Low 406 · 25.8%Moderate 410 · 26%High 124 · 7.9%

Corticosteroids vs placebo

Diarrhoea (grade 2+) · Men with prostate cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Corticosteroids vs placebo

QoL · Men with prostate cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Steroids with or without azathioprine vs cyclosporine A

Proportion of participants achieving control of inflammation (higher number of events is better) · NIIPPU

It is very uncertain whether steroids with or without azathioprine changes proportion of participants achieving control of inflammation (higher… compared with cyclosporine A (very low certainty).

1 finding from 1 review

Non‐biologic, steroid‐sparing therapies for non‐infectious intermediate, posterior, and panuveitis in adults 2022 · Cochrane Headline outcomes only
RR 0.84 [0.7, 1.02]
2 studies · 112 participants
Very low

Steroids with or without azathioprine vs cyclosporine A

Change in BCVA (lower logMAR indicate better vision) · NIIPPU

1 finding from 1 review

Non‐biologic, steroid‐sparing therapies for non‐infectious intermediate, posterior, and panuveitis in adults 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 91 participants
Very low

Steroids with or without azathioprine vs cyclosporine A

Proportion of participants achieving a 2‐line improvement in visual acuity (Snellen chart) (higher scores indicate better vision) · NIIPPU

The review found no eligible studies for this question.

1 finding from 1 review

Non‐biologic, steroid‐sparing therapies for non‐infectious intermediate, posterior, and panuveitis in adults 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Steroids with or without azathioprine vs cyclosporine A

Proportion of participants with confirmed macular edema (lower number of events is better) · NIIPPU

The review found no eligible studies for this question.

1 finding from 1 review

Non‐biologic, steroid‐sparing therapies for non‐infectious intermediate, posterior, and panuveitis in adults 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Steroids with or without azathioprine vs cyclosporine A

Proportion of participants achieving steroid‐sparing control (higher number of events is better) · NIIPPU

It is very uncertain whether steroids with or without azathioprine changes proportion of participants achieving steroid‐sparing control (higher… compared with cyclosporine A (very low certainty).

1 finding from 1 review

Non‐biologic, steroid‐sparing therapies for non‐infectious intermediate, posterior, and panuveitis in adults 2022 · Cochrane Headline outcomes only
RR 0.64 [0.33, 1.25]
1 study · 21 participants
Very low

Steroids with or without azathioprine vs cyclosporine A

Proportion of participants experiencing complications or requiring cessation of medication (lower number of events is better) · NIIPPU

It is very uncertain whether steroids with or without azathioprine changes proportion of participants experiencing complications or requiring… compared with cyclosporine A (very low certainty).

1 finding from 1 review

Non‐biologic, steroid‐sparing therapies for non‐infectious intermediate, posterior, and panuveitis in adults 2022 · Cochrane Headline outcomes only
RR 0.85 [0.21, 3.45]
2 studies · 91 participants
Very low

Strategies to increase use of antenatal corticosteroids vs usual care

Perinatal mortality · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids probably leads to higher perinatal death (at population level) compared with routine (usual) care (moderate certainty).

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
RR 1.11 [1.04, 1.19]
1 study · 100705 participants
Moderate

Strategies to increase use of antenatal corticosteroids vs usual care

Offspring mortality, early neurodevelopmental morbidity or late neurodevelopmental morbidity · women at risk of preterm birth

The review found no eligible studies for this question.

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Strategies to increase use of antenatal corticosteroids vs usual care

Offspring mortality or severe neonatal morbidity · women at risk of preterm birth

The review found no eligible studies for this question.

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Strategies to increase use of antenatal corticosteroids vs usual care

Neonatal death (death within the first 28 days of life) · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids probably leads to higher neonatal death before 28 days (at population level) compared with routine (usual) care (moderate certainty).

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
RR 1.12 [1.02, 1.23]
1 study · 100705 participants
Moderate

Strategies to increase use of antenatal corticosteroids vs usual care

Stillbirth · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids probably leads to higher stillbirth (at population level) compared with routine (usual) care (moderate certainty).

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
RR 1.11 [1.02, 1.21]
1 study · 100705 participants
Moderate

Strategies to increase use of antenatal corticosteroids vs usual care

Appropriate ACS treatment (women) · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids may leads to higher appropriate ACS treatment (women) compared with routine (usual) care (low certainty).

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
RR 4.34 [3.59, 5.25]
1 study · 4389 participants
Low

Strategies to increase use of antenatal corticosteroids vs usual care

Inappropriate ACS treatment (women) · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids may leads to higher inappropriate ACS treatment (women) compared with routine (usual) care (low certainty).

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
RR 9.11 [8.04, 10.33]
1 study · 89237 participants
Low

Strategies to increase use of antenatal corticosteroids vs usual care

Maternal infection or inflammation (at population level) · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids may leads to higher maternal infection or inflammation (at population level) compared with routine (usual) care (low certainty).

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
RR 1.49 [1.32, 1.68]
1 study · 99742 participants
Low

Strategies to increase use of antenatal corticosteroids vs usual care

Maternal death · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids showed no clear difference in maternal mortality (at population level) compared with routine (usual) care (low certainty).

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
RR 1.11 [0.64, 1.92]
1 study · 99742 participants
Low

Corticosteroids vs control

Infectious complications · people with inflammatory bowel disease

It is very uncertain whether risk of postoperative infectious complications: corticosteroids changes overall infectious complications within 30 days of surgery compared with control (very low certainty).

3 findings from 1 review

Risk of postoperative infectious complications from medical therapies in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
OR 1.4 [1.23, 1.6]
41 studies · 41 participants
Very low
Risk of postoperative infectious complications from medical therapies in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
OR 1.7 [1.38, 2.09]
17 studies · 17 participants
Low
Risk of postoperative infectious complications from medical therapies in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
OR 1.22 [1.03, 1.45]
24 studies · 24 participants
Very low

Corticosteroids vs control

Incisional infections and wound dehiscence within 30 days of surgery · people with inflammatory bowel disease

It is very uncertain whether risk of postoperative infectious complications: corticosteroids changes incisional infections and wound dehiscence within 30 days of surgery compared with control (very low certainty).

1 finding from 1 review

Risk of postoperative infectious complications from medical therapies in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
OR 1.41 [0.72, 2.74]
7 studies · 7 participants
Very low

Corticosteroids vs control

Intra‐abdominal infectious complications within 30 days of surgery · people with inflammatory bowel disease

It is very uncertain whether risk of postoperative infectious complications: corticosteroids changes intra‐abdominal infectious complications within 30 days of surgery compared with control (very low certainty).

1 finding from 1 review

Risk of postoperative infectious complications from medical therapies in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
OR 1.53 [1.28, 1.84]
28 studies · 28 participants
Very low