Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

761 questions · 801 findings · 50 reviews · Common Mental Disorders

No studies found 125 · 15.6%GRADE not reported 34 · 4.2%Very low 226 · 28.2%Low 232 · 29%Moderate 176 · 22%High 8 · 1%

Comparison 15: NK1 receptor antagonist GR205171 vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with SAnD

It is very uncertain whether comparison 15: NK1 receptor antagonist GR205171 changes global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (very low certainty).

1 finding from 1 review

Levetiracetam vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with SAnD

Comparison 3: anticonvulsant levetiracetam showed no clear difference in global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (moderate certainty).

1 finding from 1 review

Evidence‐based psychological interventions vs any comparator

Diagnosis of depression · Children or adolescents

Evidence‐based psychological interventions probably leads to lower evidence‐based psychological interventions versus any comparator… compared with any comparator (moderate certainty).

3 findings from 1 review

Evidence‐based psychological interventions vs any comparator

Evidence‐based psychological interventions versus any comparator (Universal programmes) ‐ self‐rated depression scores (higher score is equivalent to a poorer outcome) · Children or adolescents
1 finding from 1 review

Therapist‐supported ICBT vs waiting list, attention, information, or online discussion group only control

Clinically important improvement in anxiety at post‐treatment Indexed by a standardized interview or clinically accepted measure cut‐off score1 · patients with anxiety disorders

Therapist‐supported ICBT may leads to higher clinically important improvement in anxiety at post‐treatment… compared with waiting list, attention, information, or online discussion group… (low certainty).

1 finding from 1 review

Therapist‐supported ICBT vs face‐to‐face CBT

Clinically important improvement in anxiety at post‐treatment Indexed by a standardized interview or clinically accepted measure cut‐off score1 · adults with anxiety disorders

Therapist‐supported ICBT showed no clear difference in clinically important improvement in anxiety at post‐treatment… compared with face‐to‐face CBT (low certainty).

1 finding from 1 review