It is very uncertain whether benzoyl peroxide changes withdrawal due to adverse effects (long‐term data) Treatment… compared with adapalene (very low certainty).
It is very uncertain whether benzoyl peroxide changes total number of participants with any adverse events (long‐term… compared with adapalene (very low certainty).
Benzoyl peroxide showed no clear difference in participant's global self‐assessment of improvement (long‐term data) compared with clindamycin (low certainty).
It is very uncertain whether benzoyl peroxide changes withdrawal due to adverse effects (long‐term data) Treatment… compared with clindamycin (very low certainty).
Benzoyl peroxide showed no clear difference in total number of participants with any adverse events (long‐term… compared with clindamycin (moderate certainty).
It is very uncertain whether azelaic acid changes participants' global self‐assessment of acne improvement Improved to… compared with adapalene (very low certainty).
Azelaic acid showed no clear difference in withdrawal for any reason (long term: treatment duration > 8 weeks) compared with clindamycin (low certainty).
Azelaic acid showed no clear difference in total number of participants who experienced at least one minor… compared with clindamycin (low certainty).
Azelaic acid showed no clear difference in participants' global self‐assessment of acne improvement Good to… compared with tretinoin (moderate certainty).
Azelaic acid showed no clear difference in withdrawal for any reason (long term: treatment duration > 8 weeks) compared with tretinoin (low certainty).
It is very uncertain whether azelaic acid changes withdrawal for any reason (long term: treatment duration > 8 weeks) compared with adapalene (very low certainty).
Salicylic acid showed no clear difference in participants' global self‐assessment of acne improvement Moderate to… compared with tretinoin (low certainty).
It is very uncertain whether salicylic acid changes total number of participants who experienced at least one minor… compared with tretinoin (very low certainty).
Glycolic acid (alpha‐hydroxy acid) showed no clear difference in participants' global self‐assessment of acne improvement Fair to… compared with salicylic‐mandelic acid (low certainty).
It is very uncertain whether glycolic acid (alpha‐hydroxy acid) changes total number of participants who experienced at least one minor… compared with salicylic‐mandelic acid (very low certainty).
Azelaic acid probably leads to lower participants' global self‐assessment of acne improvement Good or… compared with benzoyl peroxide (moderate certainty).