Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

864 questions · 884 findings · 229 reviews · Headline outcomes only

No studies found 136 · 15.4%GRADE not reported 37 · 4.2%Very low 242 · 27.4%Low 298 · 33.7%Moderate 131 · 14.8%High 40 · 4.5%

Loratadine 10 mg vs mizolastine 10 mg

Good or excellent response: intermediate‐term duration of intervention Global assessment of symptom scores · patients with chronic spontaneous urticaria

Loratadine 10 mg showed no clear difference in good or excellent response: intermediate‐term duration of… compared with mizolastine 10 mg (low certainty).

1 finding from 1 review

Loratadine 10 mg vs emedastine 2 mg

Complete cessation of urticaria: intermediate‐term duration of intervention Global assessment of symptom scores · patients with chronic spontaneous urticaria

Loratadine 10 mg showed no clear difference in complete cessation of urticaria: intermediate‐term duration of… compared with emedastine 2 mg (moderate certainty).

1 finding from 1 review

Loratadine 10 mg vs emedastine 2 mg

Good or excellent response: intermediate‐term duration of intervention Global assessment of symptom scores · patients with chronic spontaneous urticaria

Loratadine 10 mg showed no clear difference in good or excellent response: intermediate‐term duration of… compared with emedastine 2 mg (moderate certainty).

1 finding from 1 review

Loratadine 10 mg vs hydroxyzine 25 mg

Complete suppression of urticaria: short‐term duration of intervention Global assessment of symptom scores · patients with chronic spontaneous urticaria

Loratadine 10 mg showed no clear difference in complete suppression of urticaria: short‐term duration of… compared with hydroxyzine 25 mg (low certainty).

1 finding from 1 review

Tranexamic acid vs placebo

Thromboembolic events · patients with upper gastrointestinal bleeding

Tranexamic acid probably leads to higher any thromboembolic event Clinical and radiological assessment compared with placebo (moderate certainty).

1 finding from 1 review

SULPIRIDE vs placebo

Safety assessments ‐ medium term ‐ not measured · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review