Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,352 questions · 1,400 findings · 169 reviews

No studies found 309 · 22.1%GRADE not reported 115 · 8.2%Very low 350 · 25%Low 324 · 23.1%Moderate 240 · 17.1%High 62 · 4.4%

Intervention not reported

Number of participants who experienced any adverse effects related to antibiotics · Women undergoing excision of the cervical transformation zone for cervical neoplasia

It is very uncertain whether the intervention changes number of participants who experienced any adverse effects related… (very low certainty).

1 finding from 1 review

Written information for patients (or parents of child patients) vs usual care

Antibiotics used by patients · patients (or parents of child patients) with acute upper respiratory tract infections

Written information for patients (or parents of child patients) probably leads to lower antibiotics used by patients compared with usual care (moderate certainty).

1 finding from 1 review

Written information for patients (or parents of child patients) vs usual care

Antibiotics prescribed by clinicians · patients (or parents of child patients) with acute upper respiratory tract infections

Written information for patients (or parents of child patients) may leads to lower antibiotics prescribed by clinicians compared with usual care (low certainty).

1 finding from 1 review

Written information for patients (or parents of child patients) plus prescribing feedback to clinicians vs prescribing feedback alone

Antibiotics prescribed by clinicians · patients (or parents of child patients) with acute upper respiratory tract infections

Written information for patients (or parents of child patients) plus… may leads to higher antibiotics prescribed by clinicians compared with prescribing feedback alone (low certainty).

1 finding from 1 review

Oral or topical or intraperitoneal antibiotics vs placebo/no treatment

Peritonitis · chronic peritoneal dialysis patients

Oral or topical or intraperitoneal antibiotics showed no clear difference in peritonitis (number of patients with one or more episodes) compared with placebo/no treatment (low certainty).

1 finding from 1 review

Oral or topical or intraperitoneal antibiotics vs placebo/no treatment

Exit‐site/tunnel infection · chronic peritoneal dialysis patients

Oral or topical or intraperitoneal antibiotics showed no clear difference in exit‐site/tunnel infection (number of patients with one or more… compared with placebo/no treatment (low certainty).

1 finding from 1 review

Oral or topical or intraperitoneal antibiotics vs placebo/no treatment

Catheter removal or replacement · chronic peritoneal dialysis patients

Oral or topical or intraperitoneal antibiotics showed no clear difference in catheter removal or replacement (number of patients) compared with placebo/no treatment (low certainty).

1 finding from 1 review

Comparison 1: referral or full course of antibiotics vs usual care

Neonatal mortality ‐ first dose and referral · neonates with sepsis

Comparison 1: referral or full course of antibiotics may leads to lower neonatal mortality ‐ first dose and referral compared with standard care (low certainty).

1 finding from 1 review

Comparison 1: referral or full course of antibiotics vs usual care

Neonatal mortality ‐ full course · neonates with sepsis

It is very uncertain whether comparison 1: referral or full course of antibiotics changes neonatal mortality ‐ full course compared with standard care (very low certainty).

1 finding from 1 review

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

All‐cause mortality during hospital stay · neonates with sepsis

Pentoxifylline with antibiotics (any dose or duration) may leads to lower all‐cause mortality during hospital stay compared with placebo or no intervention (low certainty).

1 finding from 1 review

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Severe intraventricular haemorrhage · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes severe intraventricular haemorrhage compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Periventricular leukomalacia · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes periventricular leukomalacia compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Length of hospital stay · neonates with sepsis

Pentoxifylline with antibiotics (any dose or duration) showed no clear difference in length of hospital stay (LOS) in days compared with placebo or no intervention (low certainty).

1 finding from 1 review

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Necrotising enterocolitis · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes necrotising enterocolitis, any Bell stage compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Retinopathy of prematurity · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes retinopathy of prematurity, any stage compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Cervical cerclage in combination with antibiotics and tocolytics vs cervical cerclage

Serious neonatal morbidity

It is very uncertain whether cervical cerclage in combination with antibiotics and tocolytics changes serious neonatal morbidity (Reported in Miller 2014 as 'composite… compared with cervical cerclage alone (very low certainty).

1 finding from 1 review

Cervical cerclage in combination with antibiotics and tocolytics vs cervical cerclage

Perinatal loss: all ‐ including miscarriages and stillbirth (Note: data not available for neonatal death)

It is very uncertain whether cervical cerclage in combination with antibiotics and tocolytics changes perinatal loss: all ‐ including miscarriages and stillbirth (Note:… compared with cervical cerclage alone (very low certainty).

1 finding from 1 review