Findings

What do systematic reviews say?

63 questions · 65 findings · 7 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 40 · 61.5%GRADE not reported 1 · 1.5%Very low 9 · 13.8%Low 11 · 16.9%Moderate 4 · 6.2%High 0 · 0%

Vitamin D 100,000 IU/month vs 12,000 IU/month

Adverse events · people with sickle cell disease

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Low

Vitamin D 100,000 IU/month vs 12,000 IU/month

Pain: presence of pain (slight or moderate) at 1 year · people with sickle cell disease

Vitamin D 100,000 IU/month showed no clear difference in presence of pain compared with 12,000 IU/month (moderate certainty).

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
RR 1 [0.62, 1.62]
1 study · 62 participants
Moderate

Vitamin D 100,000 IU/month vs 12,000 IU/month

Acute chest syndrome ( · people with sickle cell disease

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Moderate

Vitamin D 100,000 IU/month vs 12,000 IU/month

Respiratory infections · people with sickle cell disease

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Moderate

Vitamin D 100,000 IU/month vs 12,000 IU/month

HRQoL (using a validated scale) · people with sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin D 100,000 IU/month vs 12,000 IU/month

Total body BMD measured by DEXA (% change from baseline) · people with sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Vitamin A deficiency disorders · children and adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin A and beta (β)‐carotene supplementation for cystic fibrosis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Angiotensin‐converting enzyme inhibitors vs vitamin C

Serious adverse events · children with sickle cell anaemia and microalbuminuria

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for chronic kidney disease in people with sickle cell disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Angiotensin‐converting enzyme inhibitors vs vitamin C

Mortality due to any cause · children with sickle cell anaemia and microalbuminuria

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for chronic kidney disease in people with sickle cell disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Angiotensin‐converting enzyme inhibitors vs vitamin C

Quality of life · children with sickle cell anaemia and microalbuminuria

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for chronic kidney disease in people with sickle cell disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Angiotensin‐converting enzyme inhibitors vs vitamin C

Reduction or prevention of kidney disease progression · children with sickle cell anaemia and microalbuminuria

1 finding from 1 review

Interventions for chronic kidney disease in people with sickle cell disease 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 170 participants
Very low

Intervention not reported

QoL: CFQ‐R · people with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

QoL: CFQoL · people with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Adverse events · people with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

PIVKA II levels: change in PIVKA II (ng/mL) · people with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Uncarboxylated osteocalcin: change in carboxylation of osteocalcin level (% Glu‐OC) · people with cystic fibrosis

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Very low

Intervention not reported

Time to cessation of bleeding · people with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Bone mineral density: lumbar spine z score · people with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Growth and nutritional status:z‐score for height · children and adults with CF

1 finding from 1 review

Vitamin A and beta (β)‐carotene supplementation for cystic fibrosis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Low

Intervention not reported

Mortality · children and adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin A and beta (β)‐carotene supplementation for cystic fibrosis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found