Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

57 questions · 60 findings · 5 reviews · Neonatal

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 8 · 13.3%Low 36 · 60%Moderate 9 · 15%High 7 · 11.7%

Intramuscular vitamin K vs intravenous vitamin K

Presence of PIVKA II at day 25 ‐ 0.2 mg IV versus 0.5 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in presence of PIVKA II at day 25 ‐ 0.2 mg IV versus 0.5 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Vitamin D given to infants vs placebo or no treatment

Hypercalcaemia · term breastfed infants to prevent vitamin D deficiency and improve bone health

Vitamin D given to infants showed no clear difference in adverse effects (hypercalcaemia) compared with placebo or no treatment (low certainty).

1 finding from 1 review

Vitamin D given to lactating mothers vs placebo or no treatment

Nutritional rickets ‐ radiological · term breastfed infants to prevent vitamin D deficiency and improve bone health

It is very uncertain whether vitamin D given to lactating mothers changes nutritional rickets ‐ radiological compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Vitamin D given to lactating mothers vs placebo or no treatment

Hypercalcaemia · term breastfed infants to prevent vitamin D deficiency and improve bone health

Vitamin D given to lactating mothers showed no clear difference in adverse effects (hypercalcaemia) compared with placebo or no treatment (low certainty).

1 finding from 1 review

Vitamin D given to lactating mothers vs placebo or no treatment

Nutritional rickets ‐ biochemical Alkaline phosphatase, calcium and phosphate levels. · term breastfed infants to prevent vitamin D deficiency and improve bone health

Vitamin D given to lactating mothers may leads to lower nutritional rickets ‐ biochemical Alkaline phosphatase, calcium and… compared with placebo or no treatment (low certainty).

1 finding from 1 review