Findings

What do systematic reviews say?

157 questions · 161 findings · 17 reviews · Neonatal

Sort:Best matchNewest Highest certainty Download CSV

No studies found 41 · 25.5%GRADE not reported 3 · 1.9%Very low 24 · 14.9%Low 37 · 23%Moderate 54 · 33.5%High 2 · 1.2%

Summary of findings table ‐ Silicone earplugs vs no earplugs

Days of initial hospitalisation · preterm or very low birth weight infants

1 finding from 1 review

Noise or sound management in the neonatal intensive care unit for preterm or very low birth weight infants 2024 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Very low

Probiotics vs control

Necrotising enterocolitis · very preterm or very low birth weight infants

1 finding from 1 review

Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
no estimate extracted
57 studies · 10918 participants
Low

Probiotics vs control

Mortality before hospital discharge · very preterm or very low birth weight infants

1 finding from 1 review

Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
no estimate extracted
54 studies · 10484 participants
Moderate

Probiotics vs control

Late‐onset invasive infection (before hospital discharge) · very preterm or very low birth weight infants

1 finding from 1 review

Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
no estimate extracted
49 studies · 9876 participants
Moderate

Probiotics vs control

Neurodevelopmental disability · very preterm or very low birth weight infants

1 finding from 1 review

Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1518 participants
Low

Prebiotic vs control

Necrotising enterocolitis · very preterm or very low birth weight infants

1 finding from 1 review

Prebiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 686 participants
Low

Prebiotic vs control

Mortality before hospital discharge · very preterm or very low birth weight infants

1 finding from 1 review

Prebiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 686 participants
Low

Prebiotic vs control

Late‐onset invasive infection (before hospital discharge) · very preterm or very low birth weight infants

1 finding from 1 review

Prebiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 686 participants
Low

Prebiotic vs control

Bayley Scales of Infant Development Mental Development Index < 85 (assessed beyond infancy) · very preterm or very low birth weight infants

1 finding from 1 review

Prebiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 76 participants
Very low

Prebiotic vs control

Bayley Scales of Infant Development Psychomotor Development Index < 85 (assessed beyond infancy) · very preterm or very low birth weight infants

1 finding from 1 review

Prebiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 68 participants
Very low

Prebiotic vs control

Cerebral palsy · very preterm or very low birth weight infants

1 finding from 1 review

Prebiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 76 participants
Very low

Intervention not reported

Necrotising enterocolitis prior to hospital discharge · very preterm (< 32 weeks' gestation) or very low birth weight (< 1500 g) infants

The intervention may leads to lower necrotising enterocolitis prior to hospital discharge (low certainty).

1 finding from 1 review

Delayed introduction of progressive enteral feeds to prevent necrotising enterocolitis in very low birth weight infants 2022 · Cochrane Headline outcomes only
RR 0.81
13 studies · 1507 participants
Low

Intervention not reported

Mortality prior to hospital discharge · very preterm (< 32 weeks' gestation) or very low birth weight (< 1500 g) infants

The intervention showed no clear difference in mortality prior to hospital discharge (low certainty).

1 finding from 1 review

Delayed introduction of progressive enteral feeds to prevent necrotising enterocolitis in very low birth weight infants 2022 · Cochrane Headline outcomes only
RR 0.97 [0.7, 1.36]
12 studies · 1399 participants
Low

Intervention not reported

Feed intolerance prior to hospital discharge · very preterm (< 32 weeks' gestation) or very low birth weight (< 1500 g) infants

The intervention may leads to lower feed intolerance prior to hospital discharge (low certainty).

1 finding from 1 review

Delayed introduction of progressive enteral feeds to prevent necrotising enterocolitis in very low birth weight infants 2022 · Cochrane Headline outcomes only
RR 0.81 [0.68, 0.97]
6 studies · 581 participants
Low

Intervention not reported

Invasive infection prior to hospital discharge · very preterm (< 32 weeks' gestation) or very low birth weight (< 1500 g) infants

The intervention probably leads to higher invasive infection prior to hospital discharge (moderate certainty).

1 finding from 1 review

Delayed introduction of progressive enteral feeds to prevent necrotising enterocolitis in very low birth weight infants 2022 · Cochrane Headline outcomes only
RR 1.44 [1.15, 1.8]
7 studies · 872 participants
Moderate

Synbiotic vs control

Necrotising enterocolitis · very preterm or very low birth weight infants

1 finding from 1 review

Synbiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2022 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 907 participants
Low

Synbiotic vs control

Mortality before hospital discharge · very preterm or very low birth weight infants

1 finding from 1 review

Synbiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2022 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 925 participants
Low

Synbiotic vs control

Late‐onset invasive infection (before hospital discharge) · very preterm or very low birth weight infants

1 finding from 1 review

Synbiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2022 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 707 participants
Very low

Synbiotic vs control

Neurodevelopmental disability · very preterm or very low birth weight infants

The review found no eligible studies for this question.

1 finding from 1 review

Synbiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Early inhaled steroids (< 2 weeks) vs placebo (among all randomised)

Oxygen requirement at 36 weeks' postmenstrual age · very low birth weight preterm neonates

Early inhaled steroids (< 2 weeks) showed no clear difference in CLD at 36 weeks' PMA oxygen dependency at 36 weeks' PMA compared with placebo (among all randomised) (moderate certainty).

1 finding from 1 review

Early administration of inhaled corticosteroids for preventing chronic lung disease in very low birth weight preterm… 2017 · Cochrane Headline outcomes only
RR 0.97 [0.62, 1.52]
5 studies · 429 participants
Moderate