Tooth survival · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
1 finding from 1 review
Change in radiographic bone defect filling (RBF) (%) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
It is very uncertain whether autologous platelet concentrates (APC) + open flap debridement (OFD) changes change in radiographic bone defect filling (RBF) (%) compared with OFD (open flap debridement) alone (very low certainty).
1 finding from 1 review
Change in radiographic bone defect filling (RBF) (%) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
The review found no eligible studies for this question.
1 finding from 1 review
Oral health-related quality of life · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
The review found no eligible studies for this question.
1 finding from 1 review
Attachment change · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
It is very uncertain whether autologous platelet concentrates (APC) + open flap debridement (OFD) changes change in clinical attachment level (CAL) (mm) compared with OFD (open flap debridement) alone (very low certainty).
1 finding from 1 review
Pocket closure (complete pocket closure) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
1 finding from 1 review
Aesthetics · Patients affected by chronic, aggressive, or early onset periodontitis, with intrabony defects having an intrabony component of at least 3…
Enamel matrix derivative (EMD; Emdogain) showed no clear difference in aesthetics compared with placebo or control (same surgical or non-surgical intervention… (low certainty).
1 finding from 1 review
Change in gingival recession (REC) · Patients affected by chronic, aggressive, or early onset periodontitis, with intrabony defects having an intrabony component of at least 3…
Enamel matrix derivative (EMD; Emdogain) showed no clear difference in change in gingival recession (REC) compared with placebo or control (same surgical or non-surgical intervention… (low certainty).
1 finding from 1 review
Marginal bone level change · Patients affected by chronic, aggressive, or early onset periodontitis, with intrabony defects having an intrabony component of at least 3…
1 finding from 1 review
Change in probing pocket depth (PPD) · Patients affected by chronic, aggressive, or early onset periodontitis, with intrabony defects having an intrabony component of at least 3…
Enamel matrix derivative (EMD; Emdogain) may leads to higher change in probing pocket depth (PPD) compared with placebo or control (same surgical or non-surgical intervention… (low certainty).
1 finding from 1 review
Change in probing attachment level (PAL) · Patients affected by chronic, aggressive, or early onset periodontitis, with intrabony defects having an intrabony component of at least 3…
Enamel matrix derivative (EMD; Emdogain) may leads to higher change in probing attachment level (PAL) compared with placebo or control (same surgical or non-surgical intervention… (low certainty).
1 finding from 1 review
Tooth loss · Patients affected by chronic, aggressive, or early onset periodontitis, with intrabony defects having an intrabony component of at least 3…
1 finding from 1 review
Postoperative complications (infection) / adverse events · Patients affected by chronic, aggressive, or early onset periodontitis, with intrabony defects having an intrabony component of at least 3…
1 finding from 1 review
No particular adverse events or infection attributable to EMD in any trial; no differences in pain, edema, hematoma, wound dehiscence or root sensitivity (Tonetti 2002).
9 studies
GRADE not reported
PAL gain < 2 mm (dichotomous) · Patients affected by chronic, aggressive, or early onset periodontitis, with intrabony defects having an intrabony component of at least 3…
Enamel matrix derivative (EMD; Emdogain) led to lower PAL gain < 2 mm (dichotomous) compared with placebo or control (same surgical or non-surgical intervention…; GRADE not reported.
1 finding from 1 review
RR 0.53 [0.34, 0.82]
6 studies
GRADE not reported
Percentage of closed pockets · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Probing pocket depth · Adults with periodontitis (chronic and aggressive)
Azithromycin + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.
3 findings from 1 review
MD -0.57 [-1.08, -0.07]
6 studies · 216 participants
GRADE not reported
MD -0.77 [-2.33, 0.79]
2 studies · 110 participants
Very low
MD -0.60 [-1.02, -0.18]
7 studies · 258 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in clinical attachment level (CAL) compared with metronidazole + SRP; GRADE not reported.
3 findings from 1 review
MD 0.34 [-0.08, 0.76]
3 studies · 75 participants
GRADE not reported
MD 1.10 [0.36, 1.84]
1 study · 27 participants
Very low
MD -0.12 [-0.72, 0.49]
2 studies · 49 participants
GRADE not reported
Probing pocket depth · Adults with periodontitis (chronic and aggressive)
It is very uncertain whether metronidazole + SRP changes probing pocket depth compared with SRP (very low certainty).
3 findings from 1 review
MD -1.11 [-2.84, 0.61]
2 studies · 47 participants
Very low
MD -0.59 [-0.95, -0.23]
4 studies · 94 participants
GRADE not reported
MD -0.10 [-0.37, 0.16]
4 studies · 108 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with aggressive periodontitis
It is very uncertain whether doxycycline + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).
3 findings from 1 review
MD -0.80 [-1.49, -0.11]
1 study · 22 participants
Very low
MD -0.61 [-1.14, -0.08]
3 studies · 65 participants
GRADE not reported
MD 0.15 [-0.53, 0.83]
2 studies · 43 participants
GRADE not reported
Percentage of closed pockets · Adults with periodontitis (chronic and aggressive)
Azithromycin + SRP showed no clear difference in percentage of closed pockets compared with SRP; GRADE not reported.
2 findings from 1 review