Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,106 questions · 1,152 findings · 69 reviews

No studies found 216 · 18.8%GRADE not reported 448 · 38.9%Very low 122 · 10.6%Low 195 · 16.9%Moderate 127 · 11%High 44 · 3.8%

Laminectomy plus radiotherapy vs radiotherapy

Reduced use of analgesics · adults with metastatic extradural spinal cord compression (single lesion, no prior radiotherapy, fit for surgery)

It is very uncertain whether laminectomy plus radiotherapy changes reduction in analgesic use compared with radiotherapy (very low certainty).

1 finding from 1 review

Laminectomy plus radiotherapy vs radiotherapy

Urinary continence One month after radiation · adults with metastatic extradural spinal cord compression (single lesion, no prior radiotherapy, fit for surgery)

It is very uncertain whether laminectomy plus radiotherapy changes urinary continence One month after treatment compared with radiotherapy (very low certainty).

1 finding from 1 review

Split‐course radiotherapy (8 fractions, 30 Gy) vs Accelerated radiotherapy

Locoregional control · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Split-course radiotherapy showed no clear difference in locoregional control compared with accelerated radiotherapy; GRADE not reported.

1 finding from 1 review

Split‐course radiotherapy (8 fractions, 30 Gy) vs Accelerated radiotherapy

Disease-free survival · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Split-course radiotherapy showed no clear difference in disease free survival compared with accelerated radiotherapy; GRADE not reported.

1 finding from 1 review

Split‐course radiotherapy (8 fractions, 30 Gy) vs Accelerated radiotherapy

Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Split-course radiotherapy showed no clear difference in total mortality compared with accelerated radiotherapy; GRADE not reported.

1 finding from 1 review