Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

173 questions · 173 findings · 16 reviews · Hepato-Biliary

No studies found 15 · 8.7%GRADE not reported 4 · 2.3%Very low 100 · 57.8%Low 42 · 24.3%Moderate 11 · 6.4%High 1 · 0.6%

Intervention not reported

Aldosterone antagonists plus loop diuretics plus systemic vasoconstrictors (No direct RCT) · people with liver cirrhosis and ascites

It is very uncertain whether the intervention changes aldosterone antagonists plus loop diuretics plus systemic… (very low certainty).

1 finding from 1 review

Intervention not reported

Aldosterone antagonists plus loop diuretics plus systemic vasoconstrictors plus paracentesis plus fluid replacement (No direct RCT) · people with liver cirrhosis and ascites

It is very uncertain whether the intervention changes aldosterone antagonists plus loop diuretics plus systemic… (very low certainty).

1 finding from 1 review

Intervention not reported

Aldosterone antagonists plus loop diuretics plus systemic vasoconstrictors plus systemic vasodilator (No direct RCT) · people with liver cirrhosis and ascites

It is very uncertain whether the intervention changes aldosterone antagonists plus loop diuretics plus systemic… (very low certainty).

1 finding from 1 review

Intervention not reported

Paracentesis plus systemic vasoconstrictors (4 RCTs; 145 participants) · people with liver cirrhosis and ascites

It is very uncertain whether the intervention changes paracentesis plus systemic vasoconstrictors (4 RCTs; 145 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Paracentesis plus systemic vasoconstrictors (1 RCT; 25 participants) · people with liver cirrhosis and ascites

It is very uncertain whether the intervention changes paracentesis plus systemic vasoconstrictors (1 RCT; 25 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Paracentesis plus systemic vasoconstrictors (3 RCTs; 114 participants) · people with liver cirrhosis and ascites

It is very uncertain whether the intervention changes paracentesis plus systemic vasoconstrictors (3 RCTs; 114 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Paracentesis plus systemic vasoconstrictors (5 RCTs; 165 participants) · people with liver cirrhosis and ascites

It is very uncertain whether the intervention changes paracentesis plus systemic vasoconstrictors (5 RCTs; 165 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Variceal bleeding 5 years · patients with chronic hepatitis C who have failed prior antiviral therapy and who have severe histologic disease (grade 3 or 4 fibrosis)…

The review found no eligible studies for this question.

1 finding from 1 review

Band ligation vs no intervention or a sham procedure

All‐cause mortality · children with portal hypertension and large oesophageal varices, without previous gastrointestinal bleeding or beta‐blocker treatment

It is very uncertain whether band ligation changes all‐cause mortality compared with sham or no intervention (very low certainty).

1 finding from 1 review

Band ligation vs no intervention or a sham procedure

Serious adverse events Idiopathic thrombocytopaenic purpura · children with portal hypertension and large oesophageal varices, without previous gastrointestinal bleeding or beta‐blocker treatment

It is very uncertain whether band ligation changes serious adverse events Idiopathic thrombocytopaenic purpura compared with sham or no intervention (very low certainty).

1 finding from 1 review

Band ligation vs no intervention or a sham procedure

Health‐related quality of life · children with portal hypertension and large oesophageal varices, without previous gastrointestinal bleeding or beta‐blocker treatment

The review found no eligible studies for this question.

1 finding from 1 review

Band ligation vs no intervention or a sham procedure

Adverse events considered non‐serious · children with portal hypertension and large oesophageal varices, without previous gastrointestinal bleeding or beta‐blocker treatment

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

No active intervention(2 RCTs, 256 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding

It is very uncertain whether the intervention changes no active intervention(2 RCTs, 256 participants) (very low certainty).

1 finding from 1 review