Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

897 questions · 966 findings · 73 reviews

No studies found 269 · 27.8%GRADE not reported 101 · 10.5%Very low 284 · 29.4%Low 180 · 18.6%Moderate 107 · 11.1%High 25 · 2.6%

Any Psychosocial plus any Pharmacological vs any Pharmachological alone compared to

use of opiate during treatment ( · patients with opioid detoxification

Any Psychosocial plus any Pharmacological probably leads to lower use of opiate during the treatment objective compared with any Pharmachological alone compared to (moderate certainty).

1 finding from 1 review

Pharmacological intervention and a form of psychotherapy (combination) vs pharmacological intervention and usual care or attention control (single)

Depression: < 50% reduction in scale scores at end of treatment (primary outcome) · people with depression after stroke
1 finding from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Depression: meeting study criteria for depression at end of · people with depression after stroke

Pharmacological intervention and non‐invasive brain stimulation… may leads to lower depression: meeting the criteria for depression at end of treatment… compared with a pharmacological intervention and sham stimulation or usual care… (low certainty).

1 finding from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Depression: < 50% reduction in scale scores at end of treatment (primary outcome) · people with depression after stroke

It is very uncertain whether pharmacological intervention and non‐invasive brain stimulation… changes depression: < 50% reduction in scale scores at end of treatment… compared with a pharmacological intervention and sham stimulation or usual care… (very low certainty).

1 finding from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Depression: mean scores at end of treatment (secondary outcome) · people with depression after stroke
1 finding from 1 review

Psychological interventions vs psychological treatment

Depression remission · health problem or population

Summary of findings table ‐ Psychological treatment 1 showed no clear difference in depression remission ‐ short term (end of treatment) compared with psychological treatment 2 (low certainty).

1 finding from 1 review

Pharmacological interventions vs placebo

Depression: meeting study criteria for depression at end of · people with depression after stroke

It is very uncertain whether pharmacological interventions changes depression: meeting study criteria for depression at end of… compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological interventions vs placebo

Depression: < 50% reduction in scale scores at end of treatment (primary outcome) · people with depression after stroke

It is very uncertain whether pharmacological interventions changes depression: < 50% reduction in scale scores at end of treatment… compared with placebo (very low certainty).

1 finding from 1 review

Ibuprofen taken pre-emptively (about 1 hour before treatment) vs Ibuprofen taken post-treatment

Rescue analgesia · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

Ibuprofen taken pre-emptively (about 1 hour before treatment) showed no clear difference in rescue analgesia compared with ibuprofen taken post-treatment; GRADE not reported.

1 finding from 1 review

Ibuprofen taken pre-emptively (about 1 hour before treatment) vs Ibuprofen taken post-treatment

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

It is very uncertain whether ibuprofen taken pre-emptively (about 1 hour before treatment) changes pain intensity (VAS 0-100 mm) compared with ibuprofen taken post-treatment (very low certainty).

3 findings from 1 review