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Evidence found and GRADE certainty

109 questions · 115 findings · 13 reviews

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No studies found 9 · 7.8%GRADE not reported 4 · 3.5%Very low 28 · 24.3%Low 40 · 34.8%Moderate 22 · 19.1%High 12 · 10.4%

Omega‐3 vs placebo

Serious adverse events "Defined as events that result in death, hospitalization, prolongation of hospitalization, or are life threatening (based on the judgment of the study physician)" (Quinn 2010) · Apathy in people with mild‐to‐moderate Alzheimer's disease

Omega‐3 PUFA supplements showed no clear difference in serious adverse events "Defined as events that result in death,… compared with placebo (high certainty).

1 finding from 1 review

LCPUFA supplemented formula vs control formula

Sweep VEP acuity at 12 months (LogMAR) ‐ DHA and AA vs normal term formula · term infants

LCPUFA supplemented formula showed no clear difference in sweep VEP acuity at 12 months (LogMAR) ‐ DHA and AA vs normal term… compared with control formula (low certainty).

1 finding from 1 review

LCPUFA supplemented formula vs control formula

Head circumference at 12 months (z scores) ‐ DHA and AA vs normal term formula · term infants

LCPUFA supplemented formula showed no clear difference in head circumference at 12 months (z scores) ‐ DHA and AA vs normal… compared with control formula (low certainty).

1 finding from 1 review

PUFA vs monounsaturated fatty acid (MUFA)

Global impression of deterioration (investigator defined global impression of deterioration) · people with multiple sclerosis

Polyunsaturated fatty acid (PUFA) showed no clear difference in global impression of deterioration (investigator defined global… compared with monounsaturated fatty acid (MUFA) (low certainty).

1 finding from 1 review