Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

281 questions · 285 findings · 20 reviews · Skin

No studies found 42 · 14.7%GRADE not reported 88 · 30.9%Very low 22 · 7.7%Low 75 · 26.3%Moderate 47 · 16.5%High 11 · 3.9%

Oral propranolol vs placebo

Clearance, as assessed by a clinician at any · infantile haemangiomas (strawberry birthmarks) of the skin

Oral propranolol probably leads to higher clearance, as assessed by a clinician at any compared with placebo (moderate certainty).

1 finding from 1 review

Oral propranolol vs topical timolol

Adverse events experienced at short or long term ‐ general adverse events 24 weeks' · infantile haemangiomas (strawberry birthmarks) of the skin

It is very uncertain whether oral propranolol changes adverse events experienced at short or long term ‐ general adverse… compared with topical timolol (very low certainty).

1 finding from 1 review

Oral propranolol vs topical timolol

Other measures of resolution, as assessed by a clinician, at any · infantile haemangiomas (strawberry birthmarks) of the skin

Oral propranolol showed no clear difference in other measures of resolution, as assessed by a clinician, at any compared with topical timolol (low certainty).

1 finding from 1 review

Oral propranolol vs placebo

A subjective measure of improvement, as assessed by the parent or child, at any · infantile haemangiomas (strawberry birthmarks) of the skin

The review found no eligible studies for this question.

1 finding from 1 review

Oral propranolol vs placebo

Adverse events experienced at short or long term ‐ Serious adverse events 24 weeks' · infantile haemangiomas (strawberry birthmarks) of the skin

Oral propranolol showed no clear difference in adverse events experienced at short or long term ‐ Serious adverse… compared with placebo (low certainty).

1 finding from 1 review

Oral propranolol vs placebo

Other measures of resolution, as assessed by a clinician, at any · infantile haemangiomas (strawberry birthmarks) of the skin

Oral propranolol showed no clear difference in other measures of resolution, as assessed by a clinician, at any compared with placebo (moderate certainty).

1 finding from 1 review