Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

101 questions · 102 findings · 38 reviews · Eyes and Vision

No studies found 20 · 19.6%GRADE not reported 0 · 0%Very low 31 · 30.4%Low 27 · 26.5%Moderate 15 · 14.7%High 9 · 8.8%

Wavefront‐guided LASIK vs wavefront‐guided PRK

Loss of 1 or more lines of BSCVA at 12 months post treatment · Adults with refractive errors

It is very uncertain whether wavefront‐guided LASIK changes proportion of eyes that had lost 1 or more lines of best… compared with wavefront‐guided PRK (very low certainty).

1 finding from 1 review

Wavefront procedures vs conventional procedures

Proportion of eyes that had lost 1 or more lines of best spectacle‐corrected visual acuity (BSCVA) posttreatment:12 months ‐ Procedure PRK · Adults with refractive errors

Wavefront procedures showed no clear difference in proportion of eyes that had lost 1 or more lines of best… compared with conventional procedures (low certainty).

1 finding from 1 review

Wavefront procedures vs conventional procedures

Proportion of eyes that had lost 1 or more lines of best spectacle‐corrected visual acuity (BSCVA) posttreatment‐procedure LASIK; Mean higher‐order aberrations (HOAs) post‐treatment, measured by machine with wavefront sensor; proportion of eyes wi... · Adults with refractive errors

The review found no eligible studies for this question.

1 finding from 1 review

Wavefront‐optimized procedures vs wavefront‐guided procedures

Loss of 1 or more lines of BSCVA at 12 months post treatment · Adults with refractive errors

Wavefront‐optimized procedures showed no clear difference in proportion of eyes that had lost 1 or more lines of best… compared with wavefront‐guided procedures (low certainty).

1 finding from 1 review

Summary of findings: bevacizumab vs ranibizumab

BCVA: gain of 15 or more ETDRS letters · people with neovascular age‐related macular degeneration

Summary of findings: bevacizumab showed no clear difference in gain of 15 or more letters visual acuity at 1 year compared with ranibizumab (high certainty).

1 finding from 1 review