Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

521 questions · 544 findings · 62 reviews

No studies found 153 · 28.1%GRADE not reported 29 · 5.3%Very low 134 · 24.6%Low 123 · 22.6%Moderate 80 · 14.7%High 25 · 4.6%

GnRHa treatment vs other medical therapies before any surgery

Preoperative bleeding: (PBAC < 75) ulipristal acetate 5 mg · women with uterine fibroids

GnRHa treatment showed no clear difference in preoperative bleeding: Reduction in bleeding to PBAC < 75 ulipristal… compared with other medical therapies before any surgery (moderate certainty).

1 finding from 1 review

GnRHa treatment vs other medical therapies before any surgery

Preoperative bleeding: Reduction in bleeding to PBAC < 75 ulipristal acetate 10 mg · women with uterine fibroids

GnRHa treatment showed no clear difference in preoperative bleeding: Reduction in bleeding to PBAC < 75 ulipristal… compared with other medical therapies before any surgery (moderate certainty).

1 finding from 1 review

Isopropyl alcohol vs Normal saline

Nausea duration (nausea‐free at end of treatment) Measured by participant self‐report or medical or nursing observation · adults and children having any type of surgical procedure under general anaesthesia, regional anaesthesia or sedation, as hospital…

The review found no eligible studies for this question.

1 finding from 1 review

Peppermint vs placebo

Nausea duration (nausea‐free at end of treatment) Measured by participant self‐report or medical or nursing observation · adults and children having any type of surgical procedure under general anaesthesia, regional anaesthesia or sedation, as hospital…

The review found no eligible studies for this question.

1 finding from 1 review

Antidepressants vs placebo: all studies

Tolerability of treatment: withdrawal for medical reasons · people with co‐occurring depression and alcohol dependence

Antidepressants showed no clear difference in tolerability of treatment: withdrawal for medical reasons compared with placebo: all studies (low certainty).

1 finding from 1 review

Intravenous thrombolytic treatment vs standard‐of‐care therapy

Symptomatic intracranial haemorrhage at · people with stroke upon awakening

Intravenous thrombolytic treatment showed no clear difference in symptomatic intracranial haemorrhage at compared with standard medical care (high certainty).

1 finding from 1 review

Strategies to integrate oral health into primary care (e.g., training/education of non-dental primary care professionals, policy/financing and health-insurance changes, colocation of dental and medical services, interprofessional and community-health-worker collaboration, teledentistry, integrated oral health assessment tools, school-based activities) vs No integration / usual care (or pre-integration baseline; many included studies uncontrolled)

Access to oral healthcare (referral pathways, documentation processes, operating efficiencies, staffing, visits for oral health issues, uptake of fluoride varnish/other preventive treatment, and visits to an oral health professional) · People of all ages and abilities served through primary care and related settings (children, pregnant women, older adults in…

Most strategies to integrate oral health into primary care were associated with improved access to oral healthcare (19 studies, narrative synthesis; ungraded).

1 finding from 1 review
  • Strategies to integrate oral health into primary care: a systematic review. 2023 All outcomes
    Primary care, community, school, and aged-care/residential/nursing-home settings
    Access to oral healthcare was the primary outcome most studied (n=19). Most studies reported results favouring the integration strategy, including improvements in referral pathways, documentation processes, operating…
    19 studies
    GRADE not reported

Surgery for Bell's palsy vs medical treatment (oral prednisolone) or no treatment

Complications and side effects · Bell's palsy

It is very uncertain whether surgery for Bell's palsy changes side effects and complications of treatmentMeasured by clinical… compared with medical treatment (oral prednisolone) or no treatment (very low certainty).

1 finding from 1 review