Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

73 questions · 74 findings · 21 reviews

No studies found 10 · 13.5%GRADE not reported 3 · 4.1%Very low 24 · 32.4%Low 17 · 23%Moderate 20 · 27%High 0 · 0%

Low tidal volume vs high tidal volume

Barotrauma (pneumothorax) · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

It is very uncertain whether low tidal volume changes barotrauma: pneumothorax compared with high tidal volume (very low certainty).

1 finding from 1 review

PEEP vs zero end‐expiratory pressure (ZEEP) during mechanical ventilation

Postoperative mortality · adult participants given general anaesthesia

It is very uncertain whether PEEP changes postoperative mortality compared with zero end‐expiratory pressure (ZEEP) during mechanical ventilation (very low certainty).

1 finding from 1 review

PEEP vs zero end‐expiratory pressure (ZEEP) during mechanical ventilation

Pneumonia · adult participants given general anaesthesia

It is very uncertain whether PEEP changes pneumonia compared with zero end‐expiratory pressure (ZEEP) during mechanical ventilation (very low certainty).

1 finding from 1 review

Oxygen‐guided lung‐recruitment maneuver vs usual care

Death at hospital discharge · preterm infants < 37 weeks' gestational age requiring conventional mechanical ventilation for respiratory distress syndrome

Oxygen‐guided lung‐recruitment maneuver showed no clear difference in mortality by hospital discharge compared with routine care (low certainty).

1 finding from 1 review

Oxygen‐guided lung‐recruitment maneuver vs usual care

Bronchopulmonary dysplasia · preterm infants < 37 weeks' gestational age requiring conventional mechanical ventilation for respiratory distress syndrome

Oxygen‐guided lung‐recruitment maneuver showed no clear difference in bronchopulmonary dysplasia compared with routine care (low certainty).

1 finding from 1 review

Prophylactic CPAP vs mechanical ventilation

Combined outcome of death and bronchopulmonary dysplasia defined as death at any time and oxygen dependency at 36 weeks' postmenstrual age · preterm infants

Prophylactic CPAP probably leads to lower combined outcome of death and bronchopulmonary dysplasia defined as… compared with mechanical ventilation (moderate certainty).

1 finding from 1 review

Prophylactic CPAP vs mechanical ventilation

Bronchopulmonary dysplasia at 36 weeks defined as oxygen dependency at 36 weeks postmenstrual age · preterm infants

Prophylactic CPAP probably leads to lower bronchopulmonary dysplasia at 36 weeks defined as oxygen dependency… compared with mechanical ventilation (moderate certainty).

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Mortality due to bleeding · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

It is very uncertain whether intrauterine balloon tamponade plus normal care (misoprostol) changes mortality due to bleeding compared with normal care (misoprostol) (very low certainty).

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Hysterectomy to control bleeding · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

It is very uncertain whether intrauterine balloon tamponade plus normal care (misoprostol) changes hysterectomy to control bleeding compared with normal care (misoprostol) (very low certainty).

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Serious maternal morbidity (renal or respiratory failure, cardiac arrest or multiple organ failure) · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

The review found no eligible studies for this question.

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Number of women with total blood loss 1000 mL or more after randomisation · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

It is very uncertain whether intrauterine balloon tamponade plus normal care (misoprostol) changes number of women with total blood loss 1000 mL or more after… compared with normal care (misoprostol) (very low certainty).

1 finding from 1 review