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What do systematic reviews say?

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Evidence found and GRADE certainty

155 questions · 157 findings · 22 reviews · Heart

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No studies found 6 · 3.8%GRADE not reported 7 · 4.5%Very low 23 · 14.6%Low 60 · 38.2%Moderate 44 · 28%High 17 · 10.8%

Ranolazine (monotherapy) vs placebo

Adverse events incidence · patients with stable angina pectoris

It is very uncertain whether ranolazine (monotherapy) changes adverse events incidence compared with placebo (very low certainty).

1 finding from 1 review

Ranolazine (monotherapy) vs placebo

Cardiovascular mortality · patients with stable angina pectoris

Ranolazine (monotherapy) showed no clear difference in cardiovascular mortality compared with placebo (low certainty).

1 finding from 1 review

Prophylactic corticosteroids vs placebo or no corticosteroids

Infectious complications · adults diagnosed with coronary artery disease or cardiac valve disease, and candidates for cardiac surgery with cardiopulmonary bypass

Prophylactic corticosteroids may leads to lower infectious complications (as defined by study authors, including… compared with placebo or no corticosteroids (low certainty).

1 finding from 1 review

Ultrafiltration (UF) vs usual care

New initiation of renal replacement therapy – at longest available · people with AHF

Ultrafiltration (UF) showed no clear difference in new initiation of renal replacement therapy – at longest available compared with usual care (UC) (low certainty).

1 finding from 1 review

Intervention not reported

Discontinuation of therapy due to adverse effects · patients in primary prevention of cardiovascular disease events

It is very uncertain whether the intervention changes discontinuation of therapy due to adverse effects (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse effects necessitating stop of therapy Patient reported

The intervention probably leads to higher adverse effects necessitating stop of therapy Patient reported (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of patients with arrhythmia: Garlicin injection plus supportive therapy versus supportive therapy alone · patients with viral myocarditis

It is very uncertain whether the intervention changes number of patients with arrhythmia: Garlicin injection plus… (very low certainty).

1 finding from 1 review

Intervention not reported

Number of patients with arrhythmia: Danhong injection plus supportive therapy versus supportive therapy alone · patients with viral myocarditis

The intervention showed no clear difference in number of patients with arrhythmia: Danhong injection plus… (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of patients with premature beat: Astragaloside injection plus supportive therapy versus Acyclovir plus supportive therapy · patients with viral myocarditis

It is very uncertain whether the intervention changes number of patients with premature beat: Astragaloside injection plus… (very low certainty).

1 finding from 1 review