Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,822 questions · 1,891 findings · 321 reviews · Headline outcomes only

No studies found 279 · 14.8%GRADE not reported 46 · 2.4%Very low 524 · 27.7%Low 571 · 30.2%Moderate 330 · 17.5%High 141 · 7.5%

Uric acid lowering therapies (UAR) vs Placebo, no intervention or usual care (with or without placebo)

Cardiovascular events · people with CKD

Uric acid lowering therapies (UAR) showed no clear difference in cardiovascular events compared with placebo, no treatment or usual care (low certainty).

1 finding from 1 review

Blood pressure‐lowering drugs (BPLDs) vs placebo or no treatment

Recurrent stroke of any type · stroke and/or TIA

Blood pressure‐lowering drugs (BPLDs) probably leads to lower recurrent stroke of any type compared with placebo or no treatment (moderate certainty).

2 findings from 1 review

Blood pressure‐lowering drugs (BPLDs) vs placebo or no treatment

Stroke, myocardial infarction, or vascular death · stroke and/or TIA

Blood pressure‐lowering drugs (BPLDs) showed no clear difference in major vascular event (composite of non‐fatal stroke, non‐fatal… compared with placebo or no treatment (high certainty).

1 finding from 1 review

Lower genital tract infection screening vs No screening

Preterm low birthweight (below or equal 2500 g) · pregnant women presenting for routine prenatal care

Lower genital tract infection screening probably leads to lower preterm low birthweight (below or equal 2500 g) compared with no screening (moderate certainty).

1 finding from 1 review

Lower genital tract infection screening vs No screening

Preterm very low birthweight (below or equal 1500 g) · pregnant women presenting for routine prenatal care

Lower genital tract infection screening probably leads to lower preterm very low birthweight (below or equal 1500 g) compared with no screening (moderate certainty).

1 finding from 1 review

Transfer from incubator to cot at lower vs higher body weight

Proportion of infants having at least one episode of low temperature requiring overhead heater use · patients with preterm infants

Transfer from incubator to cot at lower showed no clear difference in proportion of infants having at least one episode of low temperature… compared with higher body weight (high certainty).

1 finding from 1 review

Transfer from incubator to cot at lower vs higher body weight

Proportion of infants having at least one episode of returning to incubator · patients with preterm infants

Transfer from incubator to cot at lower showed no clear difference in proportion of infants having at least one episode of returning to… compared with higher body weight (moderate certainty).

1 finding from 1 review