Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

227 questions · 239 findings · 17 reviews · Orthodontics

No studies found 54 · 22.6%GRADE not reported 122 · 51%Very low 37 · 15.5%Low 19 · 7.9%Moderate 7 · 2.9%High 0 · 0%

Hyperbaric oxygen (following replantation) vs control

Periodontal healing at 12 months · People with avulsed and replanted permanent (front) teeth

It is very uncertain whether hyperbaric oxygen (following replantation) changes periodontal healing at 12 months compared with control (very low certainty).

1 finding from 1 review

Two-band palatal expander with slow expansion vs Two-band palatal expander with rapid expansion

Molar expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…
1 finding from 1 review
  • Orthodontic treatment for posterior crossbites 2021 · Cochrane All outcomes
    7 months after start of treatment
    Martina 2012: slow 6.3 mm (SD 2.1) vs rapid 5.7 mm (SD 1.6); reported as no statistically significant difference in text (PUB2 MD 0.60, 95% CI -0.85 to 2.05); Table 1 lists P<0.001 (discrepant)
    1 study · 26 participants
    GRADE not reported

Indirect bonding using flowable composite adhesive (Opal Bond MV) vs Direct bonding (conventional, Transbond XT)

White spot lesion formation (QLF: fluorescence loss, lesion area) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Indirect bonding with a flowable adhesive favored less QLF-measured demineralization, with certainty not graded.

1 finding from 1 review

Resin infiltration vs Pre-treatment baseline before infiltration (T0); pooled as a within-arm before/after change

Lightness/brightness change of white spot lesion (luminosity L*, T0 to T1) · Patients with post-orthodontic white spot lesions and permanent dentition

ICON resin infiltration showed no statistically significant change in lightness/brightness of post-orthodontic white spot lesions at 6 months (pooled Cohen's d/SMD -0.001, 95% CI -0.23 to 0.23; 3 studies, 330 teeth; I2=97%); not GRADE-rated.

1 finding from 1 review

Resin infiltration vs Pre-treatment baseline before infiltration (T0); pooled as a within-arm before/after change

Color change of white spot lesion (color difference, T0 to T1) · Patients with post-orthodontic white spot lesions and permanent dentition

ICON resin infiltration significantly improved the color of post-orthodontic white spot lesions at 6 months (pooled Cohen's d/SMD 1.36, 95% CI 1.14 to 1.59; 4 studies, 458 teeth), although heterogeneity was very high (I2=98%) with a heavy outlier (Kannan); not GRADE-rated.

1 finding from 1 review

Fixed bonded Hyrax appliance followed by U-bow activator therapy vs no treatment

Canine expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…

Fixed bonded Hyrax appliance followed by U-bow activator therapy showed no clear difference in canine expansion compared with no treatment; GRADE not reported.

1 finding from 1 review
  • Orthodontic treatment for posterior crossbites 2021 · Cochrane All outcomes
    12 months after start of treatment
    U-bow activator 3.6 mm vs untreated 1 mm; P<0.001 (no SD reported); significant in favour of treatment
    1 study · 66 participants
    GRADE not reported

Fixed bonded Hyrax appliance followed by U-bow activator therapy vs no treatment

Molar expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…

Fixed bonded Hyrax appliance followed by U-bow activator therapy showed no clear difference in molar expansion compared with no treatment; GRADE not reported.

1 finding from 1 review
  • Orthodontic treatment for posterior crossbites 2021 · Cochrane All outcomes
    12 months after start of treatment
    U-bow activator 5.1 mm vs untreated 0.8 mm; P<0.001 (no SD reported); significant in favour of treatment
    1 study · 66 participants
    GRADE not reported

Indirect bonding using flowable composite adhesive (Opal Bond MV) vs Direct bonding (conventional, Transbond XT)

White spot lesion formation (QLF: fluorescence loss, lesion area) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)

A single RCT found indirect bonding with flowable composite reduced white spot lesion formation versus direct bonding (ungraded).

1 finding from 1 review

Psychological intervention: structured telephone call (verbal follow‐up and reassurance) vs placebo or no intervention

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

The review found no eligible studies for this question.

1 finding from 1 review

Anorexia nervosa (as exposure; diagnosed by DSM-III/III-R/IV/V) vs Healthy controls

Salivary flow rate (stimulated) · Patients with anorexia nervosa aged >=12 years (mean age ~18.4; entirely female in reported data), general community-dwelling population

Stimulated salivary flow rate was significantly lower in anorexia nervosa patients than controls, but only unstimulated flow was meta-analyzed; this outcome is ungraded.

1 finding from 1 review

Anorexia nervosa (as exposure; diagnosed by DSM-III/III-R/IV/V) vs Healthy controls

Salivary flow rate (unstimulated) · Patients with anorexia nervosa aged >=12 years (mean age ~18.4; entirely female in reported data), general community-dwelling population

Anorexia nervosa probably reduces unstimulated salivary flow rate versus healthy controls (MD -0.27 ml/min, 95% CI -0.31 to -0.24; moderate certainty).

1 finding from 1 review

Part-time clear plastic (removable) retainer vs Any type of fixed (bonded) retainer

Adverse effects on oral health: Gingival Index (lower arch) · People who had received fixed appliance orthodontic treatment

It is very uncertain whether part-time clear plastic (removable) retainer changes adverse effects on oral health: Gingival Index (lower arch) compared with any type of fixed (bonded) retainer (very low certainty).

1 finding from 1 review

Fibre-reinforced composite fixed (bonded) retainer vs Multistrand / spiral wire fixed (bonded) retainer

Patient satisfaction (measured by patient satisfaction or aesthetic scales) · People who had received fixed appliance orthodontic treatment

It is very uncertain whether fibre-reinforced composite fixed (bonded) retainer changes patient satisfaction: aesthetics (VAS 0-10 cm, lower arch) compared with multistrand / spiral wire fixed (bonded) retainer (very low certainty).

1 finding from 1 review

Part-time clear plastic (removable) retainer vs Any type of fixed (bonded) retainer

Stability: Little's Irregularity Index (lower arch) · People who had received fixed appliance orthodontic treatment

It is very uncertain whether part-time clear plastic (removable) retainer changes stability: Little's Irregularity Index (lower arch) compared with any type of fixed (bonded) retainer (very low certainty).

1 finding from 1 review

CAD/CAM nitinol fixed (bonded) retainer vs Multistrand / spiral wire fixed (bonded) retainer

Survival of retainers (failure, lower arch) · People who had received fixed appliance orthodontic treatment

It is very uncertain whether CAD/CAM nitinol fixed (bonded) retainer changes survival of retainers (failure, lower arch) compared with conventional/analogue multistrand fixed (bonded) retainer (very low certainty).

1 finding from 1 review

Full-time clear plastic (removable) retainer vs Any type of fixed (bonded) retainer

Survival of retainers (failure, lower arch) · People who had received fixed appliance orthodontic treatment

It is very uncertain whether full-time clear plastic (removable) retainer changes survival of retainers (failure, lower arch) compared with any type of fixed (bonded) retainer (very low certainty).

1 finding from 1 review

Fibre-reinforced composite fixed (bonded) retainer vs Multistrand / spiral wire fixed (bonded) retainer

Survival of retainers (failure, lower arch) · People who had received fixed appliance orthodontic treatment

Fibre-reinforced composite fixed (bonded) retainer showed no clear difference in survival of retainers (failure, lower arch) compared with multistrand / spiral wire fixed (bonded) retainer (low certainty).

1 finding from 1 review

Part-time clear plastic (removable) retainer vs Any type of fixed (bonded) retainer

Survival of retainers (failure, lower arch) · People who had received fixed appliance orthodontic treatment

It is very uncertain whether part-time clear plastic (removable) retainer changes survival of retainers (failure, lower arch) compared with any type of fixed (bonded) retainer (very low certainty).

1 finding from 1 review