Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

55 questions · 55 findings · 9 reviews

No studies found 16 · 29.1%GRADE not reported 4 · 7.3%Very low 16 · 29.1%Low 11 · 20%Moderate 8 · 14.5%High 0 · 0%

Pharmacological interventions vs pharmacological intervention

Clinical pregnancyMetformin plus liraglutide vs metformin Met + CC + L‐carnitine vs Met + CC + placebo · obese women with subfertility

It is very uncertain whether pharmacological intervention changes clinical pregnancyMetformin plus liraglutide vs metformin Met + CC +… compared with pharmacological intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions vs pharmacological intervention

MiscarriageMet + CC + L‐carnitine vs Met + CC + placebo · obese women with subfertility

It is very uncertain whether pharmacological intervention changes miscarriageMet + CC + L‐carnitine vs Met + CC + placebo compared with pharmacological intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions vs pharmacological intervention

Weight ‐ BMI changeMetformin plus liraglutide vs metformin Met + CC + L‐carnitine vs Met + CC + placebo Weight changeDexfenfluramine vs placebo Weight ‐ body fatMetformin plus liraglutide vs metformin · obese women with subfertility
1 finding from 1 review

Intervention not reported

Clinical pregnancy; type of antioxidant (natural conceptions and undergoing fertility treatments) ‐ N‐acetylcysteine versus L‐carnitine№ of participants: 164(1 RCT) · women with subfertility

It is very uncertain whether the intervention changes clinical pregnancy; type of antioxidant (natural conceptions and… (very low certainty).

1 finding from 1 review