Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

170 questions · 176 findings · 19 reviews · Heart

No studies found 25 · 14.2%GRADE not reported 14 · 8%Very low 32 · 18.2%Low 59 · 33.5%Moderate 34 · 19.3%High 12 · 6.8%

Homocysteine‐lowering interventions (Folic Acid, Vitamin B6 and Vitamin B12) vs placebo or usual care

Myocardial infarction · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (Vitamin B6 (pyridoxine;… showed no clear difference in myocardial infarction compared with placebo or standard care (high certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (Folic Acid, Vitamin B6 and Vitamin B12) vs placebo or usual care

Stroke · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (Vitamin B6 (pyridoxine;… leads to lower stroke compared with placebo or standard care (high certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (Folic Acid, Vitamin B6 and Vitamin B12) vs placebo or usual care

Death by any cause · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (Vitamin B6 (pyridoxine;… showed no clear difference in death by any cause compared with placebo or standard care (high certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (Folic Acid, Vitamin B6 and Vitamin B12) vs placebo or usual care

Adverse events · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (Vitamin B6 (pyridoxine;… showed no clear difference in adverse events compared with placebo or standard care (high certainty).

1 finding from 1 review

Mindfulness‐based interventions (MBIs) vs non‐active comparators

Clinical CVD events (CVD mortality and non‐fatal MI) · people at high risk of or withcardiovascular disease

It is very uncertain whether mindfulness‐based interventions (MBIs) changes clinical CVD events (CVD mortality and non‐fatal MI) compared with non‐active comparators (very low certainty).

1 finding from 1 review