Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

79 questions · 80 findings · 6 reviews · Headline outcomes only

No studies found 36 · 45%GRADE not reported 4 · 5%Very low 10 · 12.5%Low 12 · 15%Moderate 10 · 12.5%High 8 · 10%

Intermittent ICS vs placebo

Exacerbations requiring oral corticosteroids ‐ School‐age children · School‐aged children and adults

Intermittent ICS showed no clear difference in exacerbations requiring oral corticosteroids ‐ School‐age children compared with placebo (low certainty).

1 finding from 1 review

Intermittent LTRA vs placebo

Number of participants experiencing one or more episode requiring treatment with oral steroids · episodic viral wheeze in children

Intermittent LTRA showed no clear difference in number of participants experiencing one or more episode requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Intermittent 'as needed' ICS vs daily ICS

Number of participants experiencing one or more episode requiring treatment with oral steroids · Children and adults with persistent asthma.

Intermittent 'as needed' ICS showed no clear difference in patients with 1 or more exacerbations requiring oral corticosteroids… compared with daily ICS (low certainty).

1 finding from 1 review

Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo

Recurrent seizure at 6 months · children with febrile seizures

Intermittent rectal diclofenac showed no clear difference in recurrent seizure at 6 months compared with placebo, followed by oral ibuprofen, paracetamol, or placebo after 8… (high certainty).

1 finding from 1 review

Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo

Recurrent seizure at 12 months · children with febrile seizures

Intermittent rectal diclofenac showed no clear difference in recurrent seizure at 12 months compared with placebo, followed by oral ibuprofen, paracetamol, or placebo after 8… (high certainty).

1 finding from 1 review

Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo

Recurrent seizure at 18 months · children with febrile seizures

Intermittent rectal diclofenac showed no clear difference in recurrent seizure at 18 months compared with placebo, followed by oral ibuprofen, paracetamol, or placebo after 8… (high certainty).

1 finding from 1 review

Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo

Recurrent seizure at 24 months · children with febrile seizures

Intermittent rectal diclofenac showed no clear difference in recurrent seizure at 24 months compared with placebo, followed by oral ibuprofen, paracetamol, or placebo after 8… (high certainty).

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Low birthweight · Women receiving supplements in pregnancy

Any intermittent iron regimen (with or without other vitamins and… showed no clear difference in low birthweight (less than 2500 g) compared with daily regimen (with same vitamins and minerals)‐infant outcomes (low certainty).

1 finding from 1 review