Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

257 questions · 270 findings · 42 reviews · Headline outcomes only

No studies found 75 · 27.8%GRADE not reported 7 · 2.6%Very low 95 · 35.2%Low 50 · 18.5%Moderate 40 · 14.8%High 3 · 1.1%

Information or education intervention as part of a complex intervention vs complex intervention without information or education

Patient or carer satisfaction with information provided CCFNI (between day 3 and day 5); scale from 14 to 56 Lower scores indicate increased satisfaction. FS‐ICU 24 (90 days after randomisation); scale from 0 to 100 Lower scores indicate less sati... · adult ICU patients and their carers
1 finding from 1 review

Intervention not reported

Discharge to an increased level of care · Improving outcomes in older adult people admitted to a surgical service.

The intervention leads to lower discharge to an increased level of care (high certainty).

1 finding from 1 review

Combined deferasirox and deferiprone vs deferiprone and deferoxamine

Drug‐related AE: serum creatinine increased (≥ 33%) above baseline in 2 consecutive occasions · people with transfusion‐dependent thalassemia

It is very uncertain whether deferasirox and deferiprone changes drug‐related AE: serum creatinine increased (≥ 33%) above baseline… compared with deferiprone and deferoxamine (very low certainty).

1 finding from 1 review

Paliperidone palmitate vs risperidone long‐acting injection

No clinically important change Number of people whose PANSS score either increased or did not decrease by at least 30% from the beginning to the end of the trial · patients with schizophrenia

Paliperidone palmitate showed no clear difference in no clinically important change Number of people whose PANSS score… compared with risperidone long‐acting injection (low certainty).

1 finding from 1 review

Paliperidone palmitate vs placebo

No clinically important change Number of people whose PANSS score either increased or did not decrease by at least 30% from the beginning to the end of the trial · patients with schizophrenia

Paliperidone palmitate probably leads to lower no clinically important change Number of people whose PANSS score… compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Need for increased ventilatory assistance (invasive or non‐invasive) · individuals with an exacerbation of COPD

The intervention may leads to lower need for increased ventilatory assistance (invasive or non‐invasive) (low certainty).

1 finding from 1 review

Intervention not reported

Number of participants with increased cough · patients with prolonged non‐specific cough in children

The intervention showed no clear difference in number of participants with increased cough (moderate certainty).

1 finding from 1 review

Additional support vs usual care

Satisfaction with pregnancy care Pregnancy care rated as "very helpful" · women at increased risk of low birthweight babies (maternal outcomes)

Additional support probably leads to higher satisfaction with pregnancy care Pregnancy care rated as "very… compared with usual care during pregnancy (moderate certainty).

1 finding from 1 review

Additional support vs usual care

Death of a baby (stillbirth or neonatal death) report of perinatal death · women at increased risk of low birthweight babies (maternal outcomes)

Additional support showed no clear difference in stillbirth/neonatal death compared with usual care during pregnancy (low certainty).

1 finding from 1 review

Additional support vs usual care

Number of antenatal hospital admissions · women at increased risk of low birthweight babies (maternal outcomes)

Additional support probably leads to lower antenatal hospital admissions Number of admissions per woman compared with usual care during pregnancy (moderate certainty).

2 findings from 1 review