Five year remission at any time after randomisation · patients with first unprovoked seizure
Immediate treatment showed no clear difference in five‐year remission at any time after randomisation compared with controls (high certainty).
1 finding from 1 review
Seizure recurrence at 1 year after randomisation · patients with first unprovoked seizure
Immediate treatment leads to lower seizure recurrence at 1 year after randomisation compared with controls (high certainty).
1 finding from 1 review
Mortality at the end of the · patients with first unprovoked seizure
Immediate treatment showed no clear difference in mortality at the end of the compared with controls (high certainty).
1 finding from 1 review
Adverse events (control ‐ deferred treatment) · patients with first unprovoked seizure
Immediate treatment probably leads to higher adverse events (control ‐ deferred treatment) compared with controls (moderate certainty).
1 finding from 1 review
Adverse events (control ‐ no treatment) · patients with first unprovoked seizure
Immediate treatment may leads to higher adverse events (control ‐ no treatment) compared with controls (low certainty).
1 finding from 1 review
Adverse events (control ‐ placebo) · patients with first unprovoked seizure
Immediate treatment probably leads to higher adverse events (control ‐ placebo) compared with controls (moderate certainty).
1 finding from 1 review
Antibiotic use: delayed (all strategies) versus immediate antibiotics · respiratory infections
Summary of findings table ‐ Delayed antibiotics probably leads to lower antibiotic use: delayed (all strategies) versus immediate antibiotics compared with immediate antibiotics (moderate certainty).
1 finding from 1 review
Patient satisfaction: delayed (all strategies) versus immediate antibiotics · respiratory infections
Summary of findings table ‐ Delayed antibiotics showed no clear difference in patient satisfaction: delayed (all strategies) versus immediate… compared with immediate antibiotics (moderate certainty).
1 finding from 1 review
Reconsultations · respiratory infections
Summary of findings table ‐ Delayed antibiotics showed no clear difference in reconsultation rate: delayed (all strategies) versus immediate… compared with immediate antibiotics (moderate certainty).
1 finding from 1 review
Prosthesis failure · Patients who are having osseointegrated root-form dental implants
It is very uncertain whether immediate loading changes prosthesis failure compared with early loading (very low certainty).
1 finding from 1 review
Marginal bone level change · Patients who are having osseointegrated root-form dental implants
Immediate loading showed no clear difference in marginal bone level changes compared with early loading; GRADE not reported.
1 finding from 1 review
MD -0.06 [-0.16, 0.03]
3 studies
GRADE not reported
Marginal bone level change · Patients who are having osseointegrated root-form dental implants
Immediate loading led to lower marginal bone level changes compared with conventional loading; GRADE not reported.
1 finding from 1 review
MD -0.10 [-0.20, -0.01]
9 studies
GRADE not reported
Prosthesis failure · Patients who are having osseointegrated root-form dental implants
It is very uncertain whether immediate loading changes prosthesis failure compared with conventional loading (very low certainty).
1 finding from 1 review
Implant failure · Patients who are having osseointegrated root-form dental implants
Immediate loading showed no clear difference in implant failure compared with conventional loading; GRADE not reported.
1 finding from 1 review
RR 1.50 [0.60, 3.77]
10 studies
GRADE not reported
Implant failure · Patients who are having osseointegrated root-form dental implants
Immediate loading showed no clear difference in implant failure compared with early loading; GRADE not reported.
1 finding from 1 review
RR 0.65 [0.26, 1.64]
5 studies
GRADE not reported
ADHD symptoms · adults with ADHD (available evidence for participants aged between 25 to 53 years old)
1 finding from 1 review
Clinical impression: severity ‐ not reported · adults with ADHD (available evidence for participants aged between 25 to 53 years old)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Clinical impression: improvement‐ not reported · adults with ADHD (available evidence for participants aged between 25 to 53 years old)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Anxiety · adults with ADHD (available evidence for participants aged between 25 to 53 years old)
1 finding from 1 review
Depression: investigator‐rated · adults with ADHD (available evidence for participants aged between 25 to 53 years old)
1 finding from 1 review