Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

114 questions · 127 findings · 8 reviews

No studies found 13 · 10.2%GRADE not reported 0 · 0%Very low 35 · 27.6%Low 70 · 55.1%Moderate 9 · 7.1%High 0 · 0%

IUI in a stimulated cycle vs TI or expectant management

Ovarian Hyperstimulation Syndrome rate per woman ‐ not reported · participants with unexplained subfertility

It is very uncertain whether IUI in a stimulated cycle changes ovarian hyperstimulation syndrome rate per woman compared with TI or expectant management (very low certainty).

2 findings from 1 review

IUI in a stimulated cycle vs TI or expectant management

Miscarriage · participants with unexplained subfertility

IUI in a stimulated cycle showed no clear difference in miscarriage rate per couple compared with TI or expectant management (low certainty).

2 findings from 1 review

IUI in a stimulated cycle vs TI or expectant management

Ectopic pregnancy rate per couple · participants with unexplained subfertility

IUI in a stimulated cycle showed no clear difference in ectopic pregnancy rate per couple compared with TI or expectant management (low certainty).

2 findings from 1 review

IUI in a stimulated cycle vs TI or expectant management

Live birth rate per couple (all cycles)‐ clomiphene citrate or letrozole · participants with unexplained subfertility

IUI in a stimulated cycle probably leads to higher live birth rate per couple (all cycles)‐ clomiphene citrate or… compared with TI or expectant management (moderate certainty).

1 finding from 1 review

IUI in a stimulated cycle vs TI or expectant management

Live birth rate per couple · participants with unexplained subfertility

IUI in a stimulated cycle showed no clear difference in live birth rate per couple (all cycles)‐ clomiphene citrate or… compared with TI or expectant management (low certainty).

2 findings from 1 review

IUI in a stimulated cycle vs TI or expectant management

Multiple pregnancy rate · participants with unexplained subfertility

IUI in a stimulated cycle showed no clear difference in multiple pregnancy rate per couple compared with TI or expectant management (low certainty).

2 findings from 1 review

Gonadotropins with GnRH agonists vs gonadotropins alone

Multiple pregnancy rate · intrauterine insemination (IUI) in women with infertility

It is very uncertain whether gonadotropins with GnRH agonists changes multiple pregnancy rate per couple compared with gonadotropins alone (very low certainty).

1 finding from 1 review

Gonadotropins with GnRH agonists vs gonadotropins alone

Clinical pregnancy rate · intrauterine insemination (IUI) in women with infertility

It is very uncertain whether gonadotropins with GnRH agonists changes clinical pregnancy rate per couple compared with gonadotropins alone (very low certainty).

1 finding from 1 review