Cochrane · systematic review · CD012692
Interventions for unexplained infertility: a systematic review and network meta‐analysis
Wang, R, Danhof, NA, Tjon‐Kon‐Fat, RI, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
15
current version
GRADE rated
12
No studies
3
Included studies
NR
No studies 3 · 20%Ungraded 0 · 0%Very low 4 · 26.7%Low 7 · 46.7%Moderate 1 · 6.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings ‐ live birth or ongoing pregnancy
Population: couples with unexplained infertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Comparator | no estimate extracted | NR | No studies |
Expectant management | OR 1.01 [0.51, 1.98] | NR | Low Downgraded: imprecision |
OS | OR 1.2 [0.57, 2.52] | NR | Low Downgraded: imprecision |
IUI | OR 1.33 [0.67, 3.58] | NR | Low Downgraded: imprecision |
OS‐IUI | OR 1.17 [0.64, 2.12] | NR | Low Downgraded: imprecision |
Summary of findings ‐ multiple pregnancy
Population: couples with unexplained infertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Comparator | no estimate extracted | NR | No studies |
Expectant management/IUI | OR 3.07 [1, 9.41] | NR | Low Downgraded: imprecision, inconsistency |
OS | OR 1.09 [0.38, 3.15] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
OS‐IUI | OR 0.8 [0.37, 1.73] | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
Summary of findings ‐ clinical pregnancy
Population: couples with unexplained infertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Comparator | no estimate extracted | NR | No studies |
Expectant management | OR 1.64 [0.99, 2.73] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
OS | OR 0.73 [0.38, 1.42] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
IUI | OR 1.94 [1.05, 3.57] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
OS‐IUI | OR 1.3 [0.68, 2.5] | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
Summary of findings ‐ moderate/severe OHSS
Population: couples with unexplained infertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Moderate/severe OHSS | OR 2.5 [0.92, 6.76] | 5 studies · 958 participants | Moderate Downgraded: imprecision |